Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Clinical characteristics of the smooth tubercle bacilli 'Mycobacterium canettii' infection suggest the existence of an environmental reservoir
Clinical Microbiology and Infection, Volume 17, No. 7, Year 2011
Notification
URL copied to clipboard!
Description
Over a 3-year follow-up, 30 out of the 318 unique Mycobacterium tuberculosis complex isolates recovered in the Republic of Djibouti had a smooth-type morphology and were Niacine-negative, the characteristics of 'Mycobacterium canettii' strains. Unlike M. tuberculosis, 'M. canettii' grew on nutrient-poor media at 30°C, and possessed characteristic lipids. They were isolated from respiratory and extra-respiratory sites from patients with typical forms of tuberculosis. Most cases resolved with antibiotic therapy but in two human immunodeficiency virus-positive patients 'M. canettii' infection led to septicaemia and death. No cases of human-to-human transmission were observed. The proportion of tuberculosis cases caused by 'M. canettii' was higher among French patients than among Djiboutian patients. Patients with 'M. canettii' were significantly younger than those with tuberculosis caused by other M. tuberculosis complex strains. Smooth tubercle bacilli could be misidentified as non-tuberculous mycobacteria and appear to be limited to the Horn of Africa. Their characteristics are consistent with the existence of non-human sources of infection. © 2010 The Authors. Clinical Microbiology and Infection © 2010 European Society of Clinical Microbiology and Infectious Diseases.
Authors & Co-Authors
Koeck, Jean Louis
France, Villenave-d'ornon
Hôpital D'instruction Des Armées Robert Picqué
Fabre, Michel
France, Clamart
Hôpital D'instruction Des Armées Percy
Simon, Fabrice
France, Marseille
Hia Laveran a Marseille
Daffȩ, Mamadou M.
France, Toulouse
Ipbs Institut de Pharmacologie et de Biologie Structurale
Garnotel, Éric
France, Marseille
Hia Laveran a Marseille
Matan, A. B.
Djibouti
Centre Paul Faure
Gérôme, Patrick
France, Lyon Armees
Hia Desgenettes a Lyon
Bernatas, J. J.
Djibouti
Centre Paul Faure
Buisson, Yves
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
Pourcel, Christine
France, Gif-sur-yvette
Université Paris-saclay
Statistics
Citations: 90
Authors: 10
Affiliations: 8
Identifiers
Doi:
10.1111/j.1469-0691.2010.03347.x
ISSN:
1198743X
e-ISSN:
14690691
Study Design
Cohort Study
Study Locations
Djibouti