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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Liver biopsy results in patients with sickle cell disease on chronic transfusions: Poor correlation with ferritin levels
Pediatric Blood and Cancer, Volume 50, No. 1, Year 2008
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Description
Chronic transfusions are effective in preventing stroke and other complications of sickle cell disease. The aim of this study was to determine whether serum ferritin levels correlated with liver iron content in sickle cell patients on chronic transfusion. Forty-four liver biopsy specimens from 38 patients with homozygous sickle cell anemia (HbSS) and one patient with sickle thalassemia receiving chronic transfusions were studied. Five patients underwent a second liver biopsy for follow up. Three ferritin measurements were used to calculate a mean for each patient. The association between serum ferritin levels and liver iron quantitation was measured using the Spearman rank correlation, and sensitivity and specificity were determined for selected threshold values of serum ferritin. Serum ferritin levels ranged from 515 to 6076 ng/ml, liver iron concentration ranged from 1.8 to 67.97 mg/g dry weight. The amount of iron per gram liver dry weight was moderately correlated with serum ferritin values (r = 0.46). The correlation of duration of transfusion with serum ferritin (r = 0.40) and with liver iron content (r = 0.41) also indicated moderate correlation. Liver biopsy results led to changes in the management after 29/44 (66%) of the biopsies. Serum ferritin ≥2500 ng/ml predicted high liver iron content (≥7 mg/g), with a sensitivity of 62.5% and a specificity of 77.8%. We found a poor correlation between serum ferritin levels and liver iron content (LIC). Despite being on chelation therapy, many patients on chronic transfusion had high levels of liver iron. Measurement of LIC is highly recommended in these patients. © 2007 Wiley-Liss, Inc.
Authors & Co-Authors
Karam, Lina B.
United States, Ann Arbor
Michigan Medicine
Disco, Deborah
United States, Charleston
Medical University of South Carolina
Jackson, Sherron M.
United States, Charleston
Medical University of South Carolina
Lewin, David N.B.
United States, Charleston
Medical University of South Carolina
McKie, Virgil C.
United States, Augusta
Medical College of Georgia
Baker, Robert D.
United States, Buffalo
Women and Children's Hospital of Buffalo
Baker, Susan Sestini
United States, Buffalo
Women and Children's Hospital of Buffalo
Laver, Joseph H.
United States, Richmond
Virginia Commonwealth University
Nietert, Paul J.
United States, Charleston
Medical University of South Carolina
Abboud, Miguel Raul
Lebanon, Beirut
American University of Beirut Medical Center
Statistics
Citations: 70
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1002/pbc.21215
ISSN:
15455009
e-ISSN:
15455017
Research Areas
Health System And Policy
Noncommunicable Diseases