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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Anti-inflammatory Labdane Diterpenoids from Leonurus macranthus
Journal of Natural Products, Volume 78, No. 9, Year 2015
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Description
Twenty new polyoxygenated labdane diterpenoids (1-20) were isolated from the aerial parts of Leonurus macranthus. Their structures were elucidated on the basis of spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS). The absolute configurations of macranthin A (1) and 6-O-deacetylmacranthin A (2) were determined by single-crystal X-ray crystallographic analysis and a modified Moshers method, respectively. Compounds 1-9, 12, 14, and 19 showed inhibition of nitric oxide production in lipopolysaccharide-activated BV-2 microglial cells with IC50 values of 10.0-63.7 μM. © 2015 The American Chemical Society and American Society of Pharmacognosy.
Authors & Co-Authors
Ferreira, Daneel
United States, University
University of Mississippi
Zjawiony, Jordan
United States, University
University of Mississippi
Tu, Pengfei
China, Beijing
Beijing University of Chinese Medicine
Statistics
Citations: 44
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1021/acs.jnatprod.5b00635
ISSN:
01633864