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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Expression of the Erythrocyte Antigen Henshaw (He; MNS6): Serological and Immunochemical Studies
Vox Sanguinis, Volume 68, No. 3, Year 1995
Notification
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Description
Production of murine monoclonal antibodies to the low prevalence MNS antigen Henshaw (He; MNS6) has enabled more detailed study of this antigen. Using these directly hemagglutinating anti‐He, red blood cells (RBCs) from 1695 people of African origin were screened in the USA and England. The prevalence of He+ samples among these donors was 2.1%. In Natal, blood samples from 1218 black donors were screened with rabbit anti‐He. The prevalence of He+ donors in this population was 7.0%. Immunoblotting confirmed that the He antigen is carried on an erythrocyte membrane component with a molecular mass that is indistinguishable from glycophorin B. Hemagglutination and immunoblotting demonstrated that ten of 56 He+ samples tested more extensively had a reduced expression of the He antigen. The majority of He+ RBCs were S+; those He+ RBC samples that were S‐s+ more frequently had a weakened expression of He. © 1995 S. Karger AG, Basel
Authors & Co-Authors
Reid, Marion E.
United States, New York
New York Blood Center
Lomas-Francis, C.
United States, Houston
Gamma Biologicals, Inc.
Daniels, Geoffrey L.
United Kingdom, Glasgow
Mrc Blood Pressure Unit
Chen, V.
United States, Houston
Gamma Biologicals, Inc.
Shen, J.
United States, Houston
Gamma Biologicals, Inc.
Ho, Y. C.
United States, Washington, D.c.
American Red Cross
Hare, V.
United States, Washington, D.c.
American Red Cross
Batts, R.
United States, New York
New York Blood Center
Yacob, M.
United States, New York
New York Blood Center
Smart, Elizabeth A.
United Kingdom, Glasgow
Mrc Blood Pressure Unit
Green, Carole A.
South Africa, Pinetown
Natal Blood Transfusion Service
Statistics
Citations: 11
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1111/j.1423-0410.1995.tb03924.x
ISSN:
00429007
Study Design
Cross Sectional Study