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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Increased platelet and microparticle activation in HIV infection: Upregulation of P-selectin and tissue factor expression
Journal of Acquired Immune Deficiency Syndromes, Volume 59, No. 4, Year 2012
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Description
Objective: HIV-1-infected patients have an increased risk for atherothrombosis and cardiovascular disease, but the mechanism behind these risks is poorly understood. We have previously reported that expression of tissue factor (TF) on circulating monocytes is increased in persons with HIV infection and that TF expression is related to immune activation, to levels of HIV in plasma, and to indices of microbial translocation. In this study, we explore the activation state of platelets in HIV disease. Methods: Here, using flow cytometry-based assays, we measured platelet and platelet microparticle (PMP) activation in samples from HIV-1-infected donors and controls. Results: Platelets and PMPs from HIV-1-infected patients are activated (as reflected by expression of CD62 P-selectin) and also more frequently expressed the procoagulant TF than did platelets and PMPs obtained from controls. Expression of these proteins was directly related to expression of TF on monocytes, to markers of T-cell activation (CD38 and HLA-DR), and to plasma levels of soluble CD14, the coreceptor for bacterial lipopolysaccharride. Platelet and microparticle expression of TF was not related to plasma levels of HIV but expression of P-selectin was related to plasma levels of HIV; neither TF nor P-selectin expression wasrelated to CD4 T-cell count. Conclusions: Platelets and microparticles are activated in HIV infection, and this activated phenotype may contribute to the increased risk for cardiovascular and thrombotic events in this population although a role for other confounding cardiovascular risks cannot becompletely excluded. © 2012 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Mayne, Elizabeth Sarah
South Africa, Johannesburg
University of the Witwatersrand
Funderburg, Nicholas T.
United States, Cleveland
University Hospitals Case Medical Center
Sieg, Scott F.
United States, Cleveland
University Hospitals Case Medical Center
Asaad, Robert J.
United States, Cleveland
University Hospitals Case Medical Center
Kalinowska, Magdalena
United States, Cleveland
University Hospitals Case Medical Center
Rodriguez, Benigno A.
United States, Cleveland
University Hospitals Case Medical Center
Schmaier, Alvin H.
United States, Cleveland
University Hospitals Case Medical Center
Stevens, Wendy Susan
South Africa, Johannesburg
University of the Witwatersrand
Lederman, Michael M.
United States, Cleveland
University Hospitals Case Medical Center
Statistics
Citations: 131
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1097/QAI.0b013e3182439355
ISSN:
15254135
Research Areas
Infectious Diseases
Noncommunicable Diseases
Study Design
Cross Sectional Study