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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Transforming growth factor beta 1 in children with systemic lupus erythematosus: A possible relation with clinical presentation of lupus nephritis
Lupus, Volume 15, No. 9, Year 2006
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Description
Plasma and urinary (latent and active) TGF-β1 levels were assessed in 32 children with active lupus and compared to 15 healthy controls of matched age and sex. Plasma latent and active TGF-β1 levels in children with active disease were significantly lower than controls (P = 0.004 and P < 0.001 respectively). Plasma active TGF-β1 correlated negatively with Systemic Lupus Erythematosus Disease Activity Index (r = -0.38, P = 0.03). On the contrary, urinary latent and active TGF-β1 levels in children with active disease were significantly higher than controls (P < 0.001 and P = 0.003 respectively). Urinary active TGF-β1 levels correlated positively with Anti-ds DNA titre (r = 0.42, P = 0.015) and negatively with serum C3 levels (r = -0.48, P = 0.005). Patients with symptomatic nephritis had significantly elevated urinary active TGF-β1 levels in comparison to those with silent nephritis (P = 0.008). From this data we conclude that lowered plasma TGF-β1 levels may be a feature of systemic immune dysfunction in children with active lupus while increased renal production of active TGF-β1 seems to have a role in the clinical presentation of lupus nephritis. © 2006 SAGE Publications.
Authors & Co-Authors
Hammad, Ayman Mohammad
Egypt, Mansoura
Faculty of Medicine
Youssef, Hazem M.
Egypt, Mansoura
Faculty of Medicine
United Kingdom, Leven
Cameron Hospital
El.Arman, Mohammed M.
Egypt, Mansoura
Faculty of Medicine
Statistics
Citations: 40
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1177/0961203306071873
ISSN:
09612033
Research Areas
Genetics And Genomics
Maternal And Child Health