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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Histological assessment of SJL/J mice treated with the antioxidants coenzyme Q10 and resveratrol
Micron, Volume 42, No. 3, Year 2011
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Description
The muscular dystrophies (MDs) are genetic disorders of muscle degeneration due to mutations in genes that encode a wide variety of proteins. Dysferlinopathy are characterized by the absence of dysferlin in skeletal muscle and an autosomal recessive mode of inheritance. Both histological and ultrastructural pathology have been well established in dysferlinopathy patients and dysferlin-deficient animal models. To our knowledge the effect of antioxidant supplementation on this level has not been described previously. This article therefore focuses on the histopathology to reveal the effect of antioxidant supplementation. The study aimed to determine, at cellular level, the histopathological changes in the SJL/J mouse model following a 90 day trial with antioxidant supplementation. Markedly reduced inflammatory insult in the more affected quadriceps muscles of animals treated with high doses of CoQ10 and a combination of resveratrol/CoQ10 were observed. The outcome provides evidence that high doses of antioxidant supplementation resulted in decreased dystrophic markers and enhanced tissue integrity at cellular level. © 2010 Elsevier Ltd.
Authors & Co-Authors
Potgieter, Marnie
South Africa, Pretoria
Faculty of Health Sciences
Pretorius, Etheresia
South Africa, Pretoria
Faculty of Health Sciences
van der Merwe, Christiaan Frederick
South Africa, Pretoria
University of Pretoria
Beukes, Mervyn
South Africa, Pretoria
University of Pretoria
Vieira, Warren Antonio
South Africa, Pretoria
Faculty of Health Sciences
Auer, Roland E.J.
South Africa, Pretoria
University of Pretoria
Auer, M.
South Africa, Pretoria
University of Pretoria
Meyer, S.
South Africa, Pretoria
University of Pretoria
Statistics
Citations: 16
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1016/j.micron.2010.10.001
ISSN:
09684328
Research Areas
Genetics And Genomics