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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Chitosan-poly(lactide-co-glycolide) microsphere-based scaffolds for bone tissue engineering: In vitro degradation and in vivo bone regeneration studies
Acta Biomaterialia, Volume 6, No. 9, Year 2010
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Description
Natural polymer chitosan and synthetic polymer poly(lactide-co-glycolide) (PLAGA) have been investigated for a variety of tissue engineering applications. We have previously reported the fabrication and in vitro evaluation of a novel chitosan/PLAGA sintered microsphere scaffold for load-bearing bone tissue engineering applications. In this study, the in vitro degradation characteristics of the chitosan/PLAGA scaffold and the in vivo bone formation capacity of the chitosan/PLAGA-based scaffolds in a rabbit ulnar critical-sized-defect model were investigated. The chitosan/PLAGA scaffold showed slower degradation than the PLAGA scaffold in vitro. Although chitosan/PLAGA scaffold showed a gradual decrease in compressive properties during the 12-week degradation period, the compressive strength and compressive modulus remained in the range of human trabecular bone. Chitosan/PLAGA-based scaffolds were able to guide bone formation in a rabbit ulnar critical-sized-defect model. Microcomputed tomography analysis demonstrated that successful bridging of the critical-sized defect on the sides both adjacent to and away from the radius occurred using chitosan/PLAGA-based scaffolds. Immobilization of heparin and recombinant human bone morphogenetic protein-2 on the chitosan/PLAGA scaffold surface promoted early bone formation as evidenced by complete bridging of the defect along the radius and significantly enhanced mechanical properties when compared to the chitosan/PLAGA scaffold. Furthermore, histological analysis suggested that chitosan/PLAGA-based scaffolds supported normal bone formation via intramembranous formation. © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Jiang, Tao
United States, Charlottesville
University of Virginia
Nukavarapu, Syam P.
United States, Storrs
University of Connecticut
Deng, Meng
United States, Charlottesville
University of Virginia
United States, Storrs
University of Connecticut
Jabbarzadeh, Ehsan
United States, Charlottesville
University of Virginia
Kofron, Michelle D.
United States, Charlottesville
University of Virginia
Doty, Stephen B.
United States, New York
Hospital for Special Surgery - new York
ABDEL FATTAH WI, Wafa
Egypt, Giza
National Research Centre
Laurencin, Cato T.
United States, Storrs
University of Connecticut
Statistics
Citations: 149
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1016/j.actbio.2010.03.023
ISSN:
17427061