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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Occult HBV infection among a cohort of Nigerian adults
Journal of Infection in Developing Countries, Volume 3, No. 6, Year 2009
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Description
Objective: To determine markers of HBV infection and detect the presence of its occult infection in serum of a cohort of adult Nigerians. Methodology: The study involved 28 adult Nigerians with viral hepatitis (Group 1) and 28 apparently healthy adult Nigerians as controls (Group 2). Their sera were assayed for HBsAg, HBeAg, anti-HBe, anti-HBc, anti-HBs, and anti-HCV, while HBV DNA was determined in 15 patients with chronic hepatitis. Significance of differences between the patients and control subjects was assessed using Chi-square test at a 95% confidence level. Results: Sero-detection of HBsAg, HBeAg, anti-HBe and anti-HBc was higher among the patients compared to the controls. HBV infection was diagnosed by HBsAg (89%) and a duo of HBsAg and anti-HBc (100%) among the patients. Similarly, eleven and four types of different patterns of HBV markers were observed among the respective groups. Anti-HBe (9.5%), anti-HBc (14.3%), and anti-HBs (9.5%) were detected among all the subjects who were sero-negative for HBsAg. HBV DNA was also detected in 86.7% of the 15 patients with chronic hepatitis, while occult HBV infection was observed in 7.2% of the patients and none (0%) of the controls, p < 0.05. Furthermore, HCV infection occurred among subjects with all the different patterns of HBV markers, except those with occult HBV infection and natural immunity to HBV. Conclusion: This study shows that occult HBV infection is present among Nigerian adults and determination of HBsAg, anti-HBc, anti-HBe, and HBV DNA will assist in its detection. Copyright © 2009 Ola et al.
Authors & Co-Authors
Ola, Samuel Olawale
Nigeria, Ibadan
University College Hospital, Ibadan
Otegbayo, Jesse Abiodun
Nigeria, Ibadan
University College Hospital, Ibadan
Odaibo, Georgina Njideka
Nigeria, Ibadan
University College Hospital, Ibadan
Olaleye, David Olufemi
Nigeria, Ibadan
University College Hospital, Ibadan
Olubuyide, Itunu Olusola
Nigeria, Ibadan
University College Hospital, Ibadan
Summerton, Christopher B.
United Kingdom, Manchester
Trafford General Hospital
Bamgboye, Elijah Afolabi
Nigeria, Ibadan
University College Hospital, Ibadan
Statistics
Citations: 15
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.3855/jidc.415
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cohort Study