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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Early life stress and blood pressure levels in late adulthood
Journal of Human Hypertension, Volume 27, No. 2, Year 2013
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Description
Severe stress experienced in early life may have long-term consequences on adult physiological functions. We studied the long-term effects of separation on blood pressure levels in non-obese subjects who were separated temporarily in childhood from their parents during World War II (WWII). The original clinical study cohort consists of people born during 1934-1944 in Helsinki, Finland. This substudy includes 1361 non-obese subjects (body mass index <30 kg m -2). Of these, 192 (14.1%) had been evacuated abroad during WWII. The remaining subjects served as controls. Blood pressure levels and use of blood pressure medication were studied. The separated subjects had significantly higher systolic blood pressure values than the non-separated (148.6+21.5 vs 142.2+19.6 mm Hg, P<0.0001) in adult life. Those subjects separated in early childhood had markedly higher systolic and diastolic blood pressure values in adult life compared with the non-separated (154.6 vs 142.5 mm Hg; 95% confidence interval (CI) 2.6-14.7; P<0.005 and 90.8 vs 87.7 mm Hg; 95% CI 1.0-7.3; P<0.02, respectively). Systolic blood pressure was also higher in the group separated for a duration of <1 year (151.7 vs 142.2 mm Hg; 95% CI 0.0-12.4; P<0.05) compared with the non-separated. Besides being separated, age at separation and duration of separation also influenced blood pressure levels in adult life. This could be due to early hormonal and metabolic programming, during plastic periods in early life, influencing blood pressure levels in adult life. © 2013 Macmillan Publishers Limited All rights reserved.
Authors & Co-Authors
Alastalo, Hanna
Unknown Affiliation
Räikkönen, Katri
Unknown Affiliation
Pesonen, Anu Katriina
Unknown Affiliation
Osmond, Clive
Unknown Affiliation
Barker, David J.P.
Unknown Affiliation
Heinonen, Kati
Unknown Affiliation
Kajantie, Eero O.
Unknown Affiliation
Eriksson, Johan Gunnar
Unknown Affiliation
Statistics
Citations: 60
Authors: 8
Affiliations: 10
Identifiers
Doi:
10.1038/jhh.2012.6
e-ISSN:
14765527
Research Areas
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cohort Study