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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Associated morbidities in children with sickle-cell anaemia presenting with severe anaemia in a malarious area
Tropical Doctor, Volume 31, No. 1, Year 2001
Notification
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Description
A prospective study of 104 consecutive cases of patients with sickle-cell anaemia (SCA) presenting with severe anaemia (packed cell volume ≤ 15%) was carried out in the Children's Emergency Ward of the University College Hospital, Ibadan, in 1991. The patients were classified according to the type of anaemic crisis, by physical findings, serum bilirubin and reticulocyte counts. Other investigations included a blood film for malaria parasites, blood culture, radiological investigation and lumbar puncture when necessary. The most common problems associated with SCA patients in anaemic crisis were malaria and bacterial infections − 68 (66%) and 18 (17.3%) of cases, respectively. Acute chest syndrome was significantly more frequent in patients with hyperhaemolytic and acute splenic sequestration crisis compared with aplastic crisis (P < 0.05). Conjugated hyperbilirubinaemia was also significantly more frequent among patients with hyperhaemolytic crisis compared with all other anaemic crises (χ2=13.18, P=0.001). The overall case fatality was 86.5/1000 SCAs, with no fatalities in those with aplastic crisis. There were complications in six of the nine mortalities. Co-existing bacterial infections and conjugated hyperbilirubinaemia were associated with increased morbidity and mortality in patients with anaemic crisis. Patients with SCA crisis should have early evaluation and prompt treatment for associated infections. © 2001, SAGE Publications. All rights reserved.
Authors & Co-Authors
Ambe, Jose Pwavimbo
Nigeria, Maiduguri
University of Maiduguri
Fatunde, J. O.
Nigeria, Ibadan
University College Hospital, Ibadan
Sodeinde, Olugbemiro O.
Nigeria, Ibadan
University College Hospital, Ibadan
Statistics
Citations: 35
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1177/004947550103100109
ISSN:
00494755
e-ISSN:
17581133
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study