Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Induction of diverse secondary metabolites in Aspergillus fumigatus by microbial co-culture
RSC Advances, Volume 3, No. 34, Year 2013
Notification
URL copied to clipboard!
Description
An established culture of Aspergillus fumigatus MBC-F1-10 proved to be very receptive to external stimuli and reacted with the production of secondary metabolites which were undetectable when the fungus was grown under standard conditions. Firstly, co-cultivation with the type strain of Streptomyces bullii, an isolate from hyper-arid Atacama desert soil, led to the isolation of ergosterol 1, seven metabolites belonging to the diketopiperazine alkaloids; brevianamide F 2, spirotryprostatin A 3, 6-methoxy spirotryprostatin B 4, fumitremorgin C and its 12,13-dihydroxy derivative (5-6), fumitremorgin B 7, and verruculogen 8, in addition to 11-O-methylpseurotin A 9 and its new isomer 11-O-methylpseurotin A
2
10. In an independent experiment, addition of N-butyryl-dl-homoserine lactone to the culture medium led to the production of emestrins A and B (11-12). Neither microbe produced these compounds when cultured alone. The structures of all compounds were elucidated using NMR spectroscopic techniques and mass spectrometric analysis. The isolated compounds were tested for their potential antibacterial and antiprotozoal activities. © The Royal Society of Chemistry 2013.
Authors & Co-Authors
Rateb, Mostafa Ezzat M.
United Kingdom, Aberdeen
University of Aberdeen
Egypt, Beni Suef
Faculty of Pharmacy
Hallyburton, Irene
United Kingdom, Dundee
University of Dundee
Houssen, Wael E.
United Kingdom, Aberdeen
University of Aberdeen
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Bull, Alan T.
United Kingdom, Canterbury
University of Kent
Goodfellow, Michael
United Kingdom, Newcastle
Newcastle University
Santhanam, Rakesh
United Kingdom, Newcastle
Newcastle University
Jaspars, Marcel
United Kingdom, Aberdeen
University of Aberdeen
Ebel, Rainer
United Kingdom, Aberdeen
University of Aberdeen
Statistics
Citations: 106
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1039/c3ra42378f
e-ISSN:
20462069
Study Approach
Quantitative