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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Associations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium
Journal of Affective Disorders, Volume 318, Year 2022
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Description
Background: Widely used psychotropic medications for obsessive-compulsive disorder (OCD) may change the volumes of subcortical brain structures, and differently in children vs. adults. We measured subcortical volumes cross-sectionally in patients finely stratified for age taking various common classes of OCD drugs. Methods: The ENIGMA-OCD consortium sample (1081 medicated/1159 unmedicated OCD patients and 2057 healthy controls aged 6–65) was divided into six successive 6–10-year age-groups. Individual structural MRIs were parcellated automatically using FreeSurfer into 8 regions-of-interest (ROIs). ROI volumes were compared between unmedicated and medicated patients and controls, and between patients taking serotonin reuptake inhibitors (SRIs), tricyclics (TCs), antipsychotics (APs), or benzodiazepines (BZs) and unmedicated patients. Results: Compared to unmedicated patients, volumes of accumbens, caudate, and/or putamen were lower in children aged 6–13 and adults aged 50–65 with OCD taking SRIs (Cohen's d = −0.24 to −0.74). Volumes of putamen, pallidum (d = 0.18–0.40), and ventricles (d = 0.31–0.66) were greater in patients aged 20–29 receiving APs. Hippocampal volumes were smaller in patients aged 20 and older taking TCs and/or BZs (d = −0.27 to −1.31). Conclusions: Results suggest that TCs and BZs could potentially aggravate hippocampal atrophy of normal aging in older adults with OCD, whereas SRIs may reduce striatal volumes in young children and older adults. Similar to patients with psychotic disorders, OCD patients aged 20–29 may experience subcortical nuclear and ventricular hypertrophy in relation to APs. Although cross-sectional, present results suggest that commonly prescribed agents exert macroscopic effects on subcortical nuclei of unknown relation to therapeutic response. © 2022
Authors & Co-Authors
Ivanov, Iliyan S.
United States, New York
Icahn School of Medicine at Mount Sinai
Boedhoe, Premika S.W.
Netherlands, Amsterdam
Amsterdam Neuroscience
Abe, Yoshinari
Japan, Kyoto
Kyoto Prefectural University of Medicine
Alonso, Pino
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Ameis, Stephanie H.
Canada, Toronto
Centre for Addiction and Mental Health
Arnold, Paul Daniel
Canada, Calgary
Cumming School of Medicine
Balachander, Srinivas
India, Bengaluru
National Institute of Mental Health and Neuro Sciences
Baker, Justin Taylor
United States, Belmont
Mclean Hospital
Banaj, Nerisa
Italy, Rome
Irccs Fondazione Santa Lucia
Bargalló, Núria
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Batistuzzo, Marcelo Camargo
Brazil, Sao Paulo
Universidade de São Paulo
Brazil, Sao Paulo
Pontifícia Universidade Católica de São Paulo
Benedetti, Francesco
Italy, Milan
Università Vita-salute San Raffaele
Italy, Milan
Irccs Ospedale San Raffaele
Beucke, Jan Carl
Germany, Berlin
Humboldt-universität zu Berlin
Sweden, Stockholm
Karolinska Institutet
Bollettini, Irene
Italy, Milan
Irccs Ospedale San Raffaele
Brem, Silvia
Switzerland, Zurich
Universität Zürich
Brennan, Brian P.
United States, Belmont
Mclean Hospital
Buitelaar, Jan K.
Netherlands, Nijmegen
Radboud Universiteit
Calvo Escalona, Rosa M.
Spain, Barcelona
Hospital Clinic Barcelona
Cheng, Yuqi
China, Kunming
Kunming Medical University
Cho, Kang Ik Kevin
South Korea, Seoul
Seoul National University College of Medicine
United States, Boston
Brigham and Women's Hospital
South Korea, Seoul
University of Seoul
Dallaspezia, S.
Italy, Milan
Irccs Ospedale San Raffaele
Denys, Damiaan A.J.P.
Netherlands, Amsterdam
Amsterdam Neuroscience
Diniz, Juliana Belo
Brazil, Sao Paulo
Universidade de São Paulo
Ely, Benjamin Adam
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Feusner, Jamie Donald
Canada, Toronto
University of Toronto
Sweden, Stockholm
Karolinska Institutet
United States, Los Angeles
University of California, Los Angeles
Ferreira, Sónia
Portugal, Braga
Universidade do Minho
Fitzgerald, Kate Dimond
United States, Ann Arbor
University of Michigan, Ann Arbor
Fontaine, Martine
United States, New York
Columbia University
United States, New York
New York State Psychiatric Institute
Gruner, Patricia
United States, New Haven
Yale School of Medicine
Hanna, Gregory L.
United States, Ann Arbor
University of Michigan, Ann Arbor
Hirano, Yoshiyuki
Japan, Hamamatsu
Research Center for Child Mental Development
Hoexter, Marcelo Queiroz
Brazil, Sao Paulo
Universidade de São Paulo
Huyser, Chaim
Netherlands, Amsterdam
Amsterdam Neuroscience
Ikari, Keisuke
Japan, Fukuoka
Kyushu University
James, Anthony C.
United Kingdom, Oxford
University of Oxford
Jaspers-Fayer, Fern
Canada, Vancouver
The University of British Columbia
Jiang, Hongyan
China, Kunming
Kunming Medical University
Kathmann, Norbert
Germany, Berlin
Humboldt-universität zu Berlin
Kaufmann, Christian
Germany, Berlin
Humboldt-universität zu Berlin
Kim, Minah
South Korea, Seoul
Seoul National University College of Medicine
South Korea, Seoul
Seoul National University Hospital
Koch, Kathrin
Germany, Munich
Technische Universität München
Kwon, Junsoo
South Korea, Seoul
Seoul National University College of Medicine
South Korea, Seoul
University of Seoul
South Korea, Seoul
Seoul National University
Lázaro, María Luisa
Spain, Barcelona
Hospital Clinic Barcelona
Liu, Yanni
United States, Ann Arbor
University of Michigan, Ann Arbor
Lochner, Christine
South Africa, Stellenbosch
Stellenbosch University
Marsh, Rachel
United States, New York
Columbia University
United States, New York
New York State Psychiatric Institute
Martínez-Zalacaín, Ignacio
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Mataix-Cols, David
Sweden, Stockholm
Karolinska Institutet
Menchón, Jose M.
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Minuzzi, Luciano
Canada, Hamilton
Mcmaster University
MORER, A.
Spain, Barcelona
Hospital Clinic Barcelona
Morgado, Pedro
Portugal, Braga
Universidade do Minho
Nakagawa, Akiko
Japan, Hamamatsu
Research Center for Child Mental Development
Nakamae, Takashi
Japan, Kyoto
Kyoto Prefectural University of Medicine
Nakao, Tomohiro
Japan, Fukuoka
Kyushu University
Narayanaswamy, Janardhanan C.
India, Bengaluru
National Institute of Mental Health and Neuro Sciences
Nurmi, Erika L.
United States, Los Angeles
University of California, Los Angeles
Oh, Sanghoon
South Korea, Seoul
Seoul National University College of Medicine
South Korea, Daejeon
Eulji University, School of Medicine
Perriello, Chris
United States, Urbana
University of Illinois Urbana-champaign
Piacentini, John C.
United States, Los Angeles
University of California, Los Angeles
Picó-Pérez, Maria
Portugal, Braga
Universidade do Minho
Piras, Fabrizio
Italy, Rome
Irccs Fondazione Santa Lucia
Piras, Federica
Italy, Rome
Irccs Fondazione Santa Lucia
Reddy, Yemmigannur Chandrashekhar Janardhan
India, Bengaluru
National Institute of Mental Health and Neuro Sciences
Manrique, Daniela Rodriguez
Germany, Munich
Technische Universität München
Sakai, Yuki
Japan, Kyoto
Kyoto Prefectural University of Medicine
Japan, Kyoto
Advanced Telecommunications Research Institute International Atr
Shimizu, Eiji
Japan, Hamamatsu
Research Center for Child Mental Development
Simpson, Helen Blair
United States, New York
Columbia University
United States, New York
New York State Psychiatric Institute
Soreni, Noam
Unknown Affiliation
Soriano-Mas, Carles
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Spain, Barcelona
Universitat de Barcelona
Spalletta, Gianfranco
Italy, Rome
Irccs Fondazione Santa Lucia
United States, Houston
Baylor College of Medicine
Stern, Emily R.
United States, New York
Nyu Grossman School of Medicine
Stevens, Michael C.
United States, Hartford
Hartford Hospital
United States, New Haven
Yale School of Medicine
Stewart, S. Evelyn
Canada, Vancouver
The University of British Columbia
Szeszko, Philip R.
United States, New York
Icahn School of Medicine at Mount Sinai
Tolin, David F.
United States, Hartford
Hartford Hospital
United States, New Haven
Yale School of Medicine
van Rooij, Daan
Netherlands, Nijmegen
Radboud Universiteit
Veltman, Dick J.
Netherlands, Amsterdam
Amsterdam Neuroscience
Van Der Werf, Ysbrand D.
Netherlands, Amsterdam
Amsterdam Neuroscience
van Wingen, Guido A.
Netherlands, Amsterdam
Amsterdam Neuroscience
Venkatasubramanian, Ganesan
India, Bengaluru
National Institute of Mental Health and Neuro Sciences
Walitza, Susanne
Switzerland, Zurich
Universität Zürich
Wang, Zhen
China, Shanghai
Shanghai Mental Health Center
Watanabe, Anri
Japan, Kyoto
Kyoto Prefectural University of Medicine
Wolters, Lidewij H.
Netherlands, Amsterdam
Amsterdam Neuroscience
Xu, Xiufeng
China, Kunming
Kunming Medical University
Yun, Je-yeon
South Korea, Seoul
Seoul National University College of Medicine
South Korea, Seoul
Seoul National University Hospital
Zarei, Mojtaba
Iran, Tehran
Shahid Beheshti University
Zhang, Fengrui
China, Kunming
Kunming Medical University
Zhao, Qing
China, Shanghai
Shanghai Mental Health Center
Jahanshad, Neda
United States, Los Angeles
University of Southern California
Thomopoulos, Sophia I.
United States, Los Angeles
University of Southern California
Thompson, Paul M.
United States, Los Angeles
University of Southern California
Stein, Dan J.
South Africa, Cape Town
Sa Mrc Unit on Risk and Resilience in Mental Disorders
van den Heuvel, Odile A.
Netherlands, Amsterdam
Amsterdam Neuroscience
O'Neill, Joseph
United States, Los Angeles
University of California, Los Angeles
Poletti, Sara
Italy, Milan
Irccs Ospedale San Raffaele
Fridgeirsson, Egill Axfjord
Netherlands, Amsterdam
Amsterdam Neuroscience
Ikuta, Toshikazu
United States, University
University of Mississippi
De Wit, Stella J.
Netherlands, Amsterdam
Amsterdam Neuroscience
Vriend, Chris
Netherlands, Amsterdam
Amsterdam Neuroscience
Kasprzak, Selina
Netherlands, Amsterdam
Amsterdam Neuroscience
Kuno, Masaru
Japan, Hamamatsu
Research Center for Child Mental Development
Takahashi, Jumpei
Japan, Hamamatsu
Research Center for Child Mental Development
Miguel, Eurípedes Constantino
Brazil, Sao Paulo
Universidade de São Paulo
Shavitt, Roseli Gedanke
Brazil, Sao Paulo
Universidade de São Paulo
Hough, Morgan G.
United Kingdom, Oxford
Warneford Hospital
Pariente, Jose C.
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Ortiz, A. E.
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Bertolin, Sara
Spain, Hospitalet de Llobregat
Institut D'investigació Biomedica de Bellvitge
Spain, Barcelona
Universitat de Barcelona
Real, Eva
Spain, Hospitalet de Llobregat
Institut D'investigació Biomedica de Bellvitge
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Segalàs, Cinto
Spain, Hospitalet de Llobregat
Institut D'investigació Biomedica de Bellvitge
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Moreira, Pedro Silva
Portugal, Braga
Universidade do Minho
Sousa, Nuno Jorge Carvalho
Portugal, Braga
Universidade do Minho
Narumoto, Jin
Japan, Kyoto
Kyoto Prefectural University of Medicine
Yamada, Kei
Japan, Kyoto
Kyoto Prefectural University of Medicine
Tang, Jinsong
China, Hangzhou
Zhejiang University School of Medicine
Fouché, Jean Paul
South Africa, Stellenbosch
Stellenbosch University
Ha, Minji
South Korea, Seoul
College of Natural Sciences
Statistics
Citations: 7
Authors: 119
Affiliations: 57
Identifiers
Doi:
10.1016/j.jad.2022.08.084
ISSN:
01650327
Research Areas
Cancer
Maternal And Child Health
Study Design
Cross Sectional Study