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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf
Bioorganic and Medicinal Chemistry Letters, Volume 15, No. 10, Year 2005
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Description
Bioassay-guided fractionation of the EtOH extract of the stem bark of Funtumia elastica resulted in the isolation of four steroidal alkaloids, holarrhetine (1), conessine (2), holarrhesine (3) and isoconessimine (4). Their structures were determined on the basis of 1D- and 2D-NMR techniques and mass spectrometry. Compounds 1-4 exhibited in vitro antiplasmodial activity against the chloroquine-resistant strain FcB1 of Plasmodium falciparum with IC 50 values ranging from 0.97 to 3.39 μM. They showed weak cytotoxicity against a rat cell line L-6 with IC50 values ranging from 5.13 to 36.55 μM. © 2005 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Zirihi, Guédé Noël
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
Gréllier, Philippe
France, Paris
Museum National D'histoire Naturelle
Guédé-Guina, Frédéric
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
Bodo, Bernard
France, Paris
Museum National D'histoire Naturelle
Mambu, Lengo
France, Paris
Museum National D'histoire Naturelle
Statistics
Citations: 59
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1016/j.bmcl.2005.03.021
ISSN:
0960894X