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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Depression is a risk factor for incident coronary heart disease in women: An 18-year longitudinal study
Journal of Affective Disorders, Volume 196, Year 2016
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Description
Background: According to a recent position paper by the American Heart Association, it remains unclear whether depression is a risk factor for incident Coronary Heart Disease (CHD). We assessed whether a depressive disorder independently predicts 18-year incident CHD in women. Method A prospective longitudinal study of 860 women enrolled in the Geelong Osteoporosis Study (1993-2011) was conducted. Participants were derived from an age-stratified, representative sample of women (20-94 years) randomly selected from electoral rolls in South-Eastern Australia. The exposure was a diagnosis of a depressive disorder using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders. Outcomes data were collected from hospital medical records: (1) Primary outcome: a composite measure of cardiac death, non-fatal Myocardial Infarction or coronary intervention. (2) Secondary outcome: any cardiac event (un/stable angina, cardiac event not otherwise defined) occurring over the study period. Results Seven participants were excluded based on CHD history. Eighty-three participants (9.6%) recorded ≥1 cardiac event over the study period; 47 had a diagnosis that met criteria for inclusion in the primary analysis. Baseline depression predicted 18-year incidence, adjusting for (1) anxiety (adj. OR:2.39; 95% CIs:1.19-4.82), plus (2) typical risk factors (adj. OR:3.22; 95% CIs:1.45-6.93), plus (3) atypical risk factors (adj. OR:3.28; 95% CIs:1.36-7.90). This relationship held when including all cardiac events. No relationship was observed between depression and recurrent cardiac events. Conclusion The results of this study support the contention that depression is an independent risk factor for CHD incidence in women. Moreover, the strength of association between depression and CHD incidence was of a greater magnitude than any typical and atypical risk factor. © 2016 Elsevier B.V. All rights reserved.
Authors & Co-Authors
O’neil, Adrienne E.
Australia, Melbourne
University of Melbourne
Australia, Geelong
Deakin University
Australia, Clayton
Monash University
Jacka, Felice Nellie
Australia, Geelong
Deakin University
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Centre for Adolescent Health
Australia, Sydney
Black Dog Institute
Berk, Michael
Australia, Geelong
Deakin University
Australia, Clayton
Monash University
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Orygen Youth Health
Australia, Melbourne
The Florey
Lewandowski, Paul A.
Australia, Geelong
Deakin University
Statistics
Citations: 72
Authors: 4
Affiliations: 12
Identifiers
Doi:
10.1016/j.jad.2016.02.029
ISSN:
01650327
Research Areas
Health System And Policy
Mental Health
Noncommunicable Diseases
Study Design
Randomised Control Trial
Cohort Study
Study Approach
Quantitative
Participants Gender
Female