Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Deletion of the late cornified envelope genes, LCE3C and LCE3B, is associated with rheumatoid arthritis
Arthritis and Rheumatism, Volume 62, No. 5, Year 2010
Notification
URL copied to clipboard!
Description
Objective. The risk of rheumatoid arthritis (RA) is increased in the offspring of individuals affected with various autoimmune disorders, including psoriasis. Recently, the deletion of 2 genes from the late cornified envelope (LCE) gene cluster, LCE3C and LCE3B, has been associated with psoriasis in several populations. The purpose of this study was to assess whether this polymorphic gene deletion could also be involved in susceptibility to RA. Methods. We tested for association between the LCE3C-LCE3B copy number variant and a single-nucleotide polymorphism in strong linkage disequilibrium with this variant (rs4112788) and RA in 2 independent case-control data sets (197 and 400 samples from patients with RA, respectively, and 411 and 567 samples from control subjects, respectively), collected at 4 Spanish hospitals. All samples were directly typed for presence of the LCE3C-LCE3B deletion (LCE3C-LCE3B-del) by polymerase chain reaction, and association analysis was performed using the SNPassoc R package. Results. An association of homozygosity for the LCE3C-LCE3B-del and rs4112788 C allele with the risk of RA was observed in the first data set and was replicated in an independent case-control set. A combined analysis showed an overall P value of 0.0012 (odds ratio [OR] 1.45, 95% confidence interval [95% CI] 1.16-1.81) for association of the LCE3C-LCE3B-del. When the analysis was stratified for serologic data, we observed association in anti-cyclic citrullinated peptide (anti-CCP)-positive patients (P = 0.012, OR 1.51 [95% CI 1.09-2.13]) but not in anti-CCP-negative patients. Conclusion. We have identified an association between the LCE3C-LCE3B-del and RA, and we have verified a pleiotropic effect of a common genetic risk factor (LCE3C-LCE3B-del) for autoimmune diseases that is involved in both psoriasis and RA. © 2010, American College of Rheumatology.
Authors & Co-Authors
Docampo, Elisa
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Rabionet, Raquel
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Escaramis, Georgia
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Julià, Antonio
Spain, Barcelona
Hospital Universitari Vall D'hebron
González-Gay, Miguel Ángel
Spain, Lugo
Complejo Hospitalario Xeral Calde
Balsa, Alejando
Spain, Madrid
Hospital Universitario la Paz
Raya Álvarez, Enriqué G.
Spain, Granada
Hospital Universitario San Cecilio
Martin, Javier
Spain, Madrid
Consejo Superior de Investigaciones Científicas
Estivill, Xavier
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Statistics
Citations: 35
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.1002/art.27381
ISSN:
00043591
Research Areas
Genetics And Genomics
Study Design
Case-Control Study