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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Inbred mouse strains reveal biomarkers that are pro-longevity, antilongevity or role switching
Aging Cell, Volume 13, No. 4, Year 2014
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Description
Traditionally, biomarkers of aging are classified as either pro-longevity or antilongevity. Using longitudinal data sets from the large-scale inbred mouse strain study at the Jackson Laboratory Nathan Shock Center, we describe a protocol to identify two kinds of biomarkers: those with prognostic implication for lifespan and those with longitudinal evidence. Our protocol also identifies biomarkers for which, at first sight, there is conflicting evidence. Conflict resolution is possible by postulating a role switch. In these cases, high biomarker values are, for example, antilongevity in early life and pro-longevity in later life. Role-switching biomarkers correspond to features that must, for example, be minimized early, but maximized later, for optimal longevity. The clear-cut pro-longevity biomarkers we found reflect anti-inflammatory, anti-immunosenescent or anti-anaemic mechanisms, whereas clear-cut antilongevity biomarkers reflect inflammatory mechanisms. Many highly significant blood biomarkers relate to immune system features, indicating a shift from adaptive to innate processes, whereas most role-switching biomarkers relate to blood serum features and whole-body phenotypes. Our biomarker classification approach is applicable to any combination of longitudinal studies with life expectancy data, and it provides insights beyond a simplified scheme of biomarkers for long or short lifespan. © 2014 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
Authors & Co-Authors
Hirose, Misa
Germany, Lubeck
Universität zu Lübeck
Baltrusch, Simone
Germany, Rostock
Universität Rostock Uniklinikum Und Medizinische Fakultät
Ibrahim, Saleh Mohamed
Germany, Lubeck
Universität zu Lübeck
Junghanss, Christian
Germany, Rostock
Universität Rostock Uniklinikum Und Medizinische Fakultät
Wolkenhauer, Olaf
Germany, Rostock
Universität Rostock
Jaster, Robert
Germany, Rostock
Universität Rostock Uniklinikum Und Medizinische Fakultät
Köhling, Rüdiger
Germany, Rostock
Universität Rostock Uniklinikum Und Medizinische Fakultät
Kunz, Manfred
Germany, Leipzig
Universität Leipzig
Tiedge, Markus
Germany, Rostock
Universität Rostock Uniklinikum Und Medizinische Fakultät
Schofield, Paul N.
United Kingdom, Cambridge
University of Cambridge
Fuellen, Georg F.
Germany, Rostock
Universität Rostock Uniklinikum Und Medizinische Fakultät
Statistics
Citations: 15
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1111/acel.12226
ISSN:
14749718
Study Design
Cohort Study