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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Longitudinal changes in C-reactive protein, proform of eosinophil major basic protein, and pregnancy-associated plasma protein-A during weight changes in obese children
Journal of Pediatric Endocrinology and Metabolism, Volume 28, No. 3-4, Year 2015
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Description
Background: Childhood obesity is associated with several complications, including cardiovascular comorbidity. Several biomarkers, such as high-sensitive C-reactive protein (hs-CRP), proform of eosinophil major basic protein (Pro-MBP) and pregnancy associated plasma protein-A (PAPP-A), have equally been linked to increased cardiovascular susceptibility. This study investigates these biomarkers during weight loss and regain in obese children. Materials and methods: A longitudinal study during a 12-week weight loss program with a 28 months follow-up was conducted. Anthropometrics and plasma concentrations of hs-CRP, Pro-MBP, and PAPP-A were measured at baseline; at days 14, 33 and 82 during weight loss; and at months 10, 16, and 28 during follow-up. Results: Fifty-three boys and 62 girls aged 8-15 years with a median body mass index (BMI) standard deviation score (SDS) at baseline of 2.78 (boys), and 2.70 (girls) were included. Ninety children completed the weight loss program and 68 children entered the follow-up program. Pro-MBP and PAPP-A, but not hs-CRP, exhibited individual-specific levels (tracking) during weight loss and regain. The PAPP-A/Pro-MBP correlation was strong, whereas the hs-CRP/PAPP-A correlation was weak during weight fluctuations. Conclusion: Hs-CRP changes reflect weight changes. PAPP-A and Pro-MBP exhibited tracking during weight perturbations and may contribute as early risk markers of cardiovascular susceptibility. © 2015 by De Gruyter 2015.
Authors & Co-Authors
Lausten-Thomsen, Ulrik
Denmark, Copenhagen
Copenhagen University Hospital
Denmark, Copenhagen
Københavns Universitet
Hedley, P. L.
Denmark, Copenhagen
Statens Serum Institut
Hagen, Christian Munch
Denmark, Copenhagen
Statens Serum Institut
Christiansen, Michael
Denmark, Copenhagen
Statens Serum Institut
Holm, Jens Christian
Denmark, Copenhagen
Copenhagen University Hospital
Statistics
Citations: 6
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1515/jpem-2014-0249
ISSN:
0334018X
Research Areas
Maternal And Child Health
Noncommunicable Diseases
Sexual And Reproductive Health
Study Design
Cohort Study
Study Approach
Quantitative
Participants Gender
Male
Female