Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Phyto-SERM constitutes from Flemingia macrophylla
International Journal of Molecular Sciences, Volume 14, No. 8, Year 2013
Notification
URL copied to clipboard!
Description
The methanolic extract of Flemingia macrophylla roots exhibited significant estrogenic activity in the transgenic plant assay system which was comparable to the activity of soybean extract. Utilizing estrogenic activity-guided fractionation, one new compound, fleminigin, together with 23 known compounds were isolated from F. macrophylla roots' methanolic extract. The structure of the new compound was identified based on intensive spectroscopic analysis and the full spectral data for one of the isolated compounds, flemichin E, was introduced for the first time in the current investigation. The estrogenic and anti-estrogenic activities of the isolated compounds were evaluated revealing that the isolated isoflavonoids may act as partial estrogen agonists, as well as antagonists. Additionally, the anti-inflammatory and the cytotoxic activities of the isolated compounds were studied. These results suggested the potential applications of F. macrophylla extract and its isolated compounds as selective estrogen receptor modulators (SERMs). © 2013 by the authors; licensee MDPI, Basel, Switzerland.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3759874/bin/ijms-14-15578-s001.pdf
Authors & Co-Authors
Lai, Wanchun
Taiwan, Kaohsiung
Kaohsiung Medical University
Tsui, Yating
Taiwan, Kaohsiung
Kaohsiung Medical University
El-Shazly, Mohamed
Taiwan, Kaohsiung
Kaohsiung Medical University
Egypt, Cairo
Ain Shams University
Du, Yingchi
Taiwan, Kaohsiung
Kaohsiung Medical University
Hwang, Tsong Long
Taiwan, Taoyuan
Chang Gung University
Wu, Chinchung
Taiwan, Kaohsiung
Kaohsiung Medical University
Yen, Minghong
Taiwan, Kaohsiung
Kaohsiung Medical University
Lee, Ching Kuo
Taiwan, Taipei
Taipei Medical University
Hou, Mingfeng
Taiwan, Kaohsiung
Kaohsiung Medical University Chung-ho Memorial Hospital
Wu, Yangchang
Taiwan, Taichung
China Medical University
Taiwan, Taichung
China Medical University Hospital
Chang, Fangrong
Taiwan, Kaohsiung
Kaohsiung Medical University
Taiwan, Kaohsiung
Kaohsiung Medical University Chung-ho Memorial Hospital
Statistics
Citations: 12
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.3390/ijms140815578
ISSN:
16616596
e-ISSN:
14220067