Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Maintenance of HIV-specific CD4
+
T cell help distinguishes HIV-2 from HIV-1 infection
Journal of Immunology, Volume 176, No. 11, Year 2006
Notification
URL copied to clipboard!
Description
Unlike HIV-1-infected people, most HIV-2-infected subjects maintain a healthy CD4+ T cell count and a strong HIV-specific CD4+ T cell response. To define the cellular immunological correlates of good prognosis in HIV-2 infection, we conducted a cross-sectional study of HIV Gag-specific T cell function in HIV-1- and HIV-2-infected Gambians. Using cytokine flow cytometry and lymphoproliferation assays, we show that HIV-specific CD4+ T cells from HIV-2-infected individuals maintained proliferative capacity, were not terminally differentiated (CD57-), and more frequently produced IFN-γ or IL-2 than CD4+ T cells from HIV-1-infected donors. Polyfunctional (IFN-γ+/IL-2 +) HIV-specific CD4+ T cells were found exclusively in HIV-2+ donors. The disparity in CD4+ T cell responses between asymptomatic HIV-1- and HIV-2-infected subjects was not associated with differences in the proliferative capacity of HIV-specific CD8+ T cells. This study demonstrates that HIV-2-infected donors have a well-preserved and functionally heterogeneous HIV-specific memory CD4+ T cell response that is associated with delayed disease progression in the majority of infected people. Copyright © 2006 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Duvall, Melody G.
United Kingdom, Oxford
University of Oxford
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Jaye, Assan
Gambia, Banjul
Medical Research Council Laboratories Gambia
Dong, Tao
United Kingdom, Oxford
University of Oxford
Brenchley, Jason
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Alabi, Abraham Sunday
Gambia, Banjul
Medical Research Council Laboratories Gambia
Jeffries, David J.
Gambia, Banjul
Medical Research Council Laboratories Gambia
van der Sande, Marianne A.B.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Togun, Toyin Omotayo
Gambia, Banjul
Medical Research Council Laboratories Gambia
McConkey, Samuel J.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Douek, Daniel Cesar
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
McMichael, Andrew James
United Kingdom, Oxford
University of Oxford
Whittle, Hilton C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Koup, Richard A.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Rowland-Jones, Sarah Louise
United Kingdom, Oxford
University of Oxford
Gambia, Banjul
Medical Research Council Laboratories Gambia
Statistics
Citations: 105
Authors: 14
Affiliations: 3
Identifiers
Doi:
10.4049/jimmunol.176.11.6973
ISSN:
00221767
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative