Publication Details

AFRICAN RESEARCH NEXUS

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immunology and microbiology

Lack of association of VDR gene polymorphisms with thyroid autoimmune disorders: Familial and case/control studies

Journal of Clinical Immunology, Volume 28, No. 1, Year 2008

We study the association between three Vitamin D receptor gene polymorphisms (rs10735810, rs1544410, rs731236) and susceptibility to thyroid autoimmune diseases. Seventy-six affected subjects, belonging to a large family, as well as one hundred unrelated Tunisian patients and one hundred healthy Tunisian controls were genotyped. A family-based association test and a standard chi-square test were used to assess association in family and case-control data, respectively. Our results showed no significant association of the Vitamin D receptor gene polymorphisms with the susceptibility to thyroid autoimmune diseases in the family. Moreover, allele frequencies for the three polymorphisms in the Tunisian population were similar to those reported in the Tunisian control population and none was associated with the disease. These results suggest a lack of association between the Vitamin D receptor gene polymorphisms and susceptibility to thyroid autoimmune diseases in Tunisian population, in agreement with data from the UK, but in conflict with studies from the Far East. © 2007 Springer Science+Business Media, LLC.
Statistics
Citations: 34
Authors: 8
Affiliations: 4
Identifiers
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Case-Control Study