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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Plasmodium falciparum: Modulation by calcium antagonists of resistance to chloroquine, desethylchloroquine, quinine, and quinidine in vitro
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 84, No. 4, Year 1990
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Description
Intrinsic interactions of calcium antagonists (broadly defined) and quinoline-containing antimalarial drugs were evaluated against chloroquine-sensitive and chloroquine-resistant clones of Plasmodium falciparum in vitro. Verapamil, D-600 (methoxyverapamil), Ro 11-2933/001 (tiapamil analogue), chlorpromazine, SKF 21133-A (chlorpromazine analogue), and diltiazem each potentiated the efficacy of the quinoline-containing antimalarials chloroquine, desethylchloroquine, and quinine with a chloroquineresistant clone of P. falciparum, but did not affect the response of the quinoline-susceptible clone. Similar concentrations of either chlorpromazine or Ro 11-2933/001 lowered the IC50 of the resistant clone to approximately the same level as that observed for the sensitive clone for each of the quinolines tested. This reversal of resistance by many of the same calcium antagonists underscores the similarities in one mechanism of multi-drug resistance in neoplastic cells and quinoline-resistance in P. falciparum. © 1990, Royal Society of Tropical Medicine and Hygiene. All rights reserved.
Authors & Co-Authors
Kyle, Dennis E.
United States, Silver Spring
Walter Reed Army Institute of Research
Oduola, Ayoade M.J.
United States, Silver Spring
Walter Reed Army Institute of Research
Martin, Samuel K.
United States, Silver Spring
Walter Reed Army Institute of Research
Milhous, Wilbur K.
United States, Silver Spring
Walter Reed Army Institute of Research
Statistics
Citations: 76
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1016/0035-9203(90)90004-X
ISSN:
00359203
Research Areas
Health System And Policy