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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Evolution and neutralization escape of the SARS-CoV-2 BA.2.86 subvariant
Nature Communications, Volume 14, No. 1, Article 8078, Year 2023
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Description
Omicron BA.2.86 subvariant differs from Omicron BA.2 as well as recently circulating variants by over 30 mutations in the spike protein alone. Here we report on the isolation of the live BA.2.86 subvariant from a diagnostic swab collected in South Africa which we tested for escape from neutralizing antibodies and viral replication properties in cell culture. We found that BA.2.86 does not have significantly more escape relative to Omicron XBB.1.5 from neutralizing immunity elicited by either Omicron XBB-family subvariant infection or from residual neutralizing immunity of recently collected sera from the South African population. BA.2.86 does have extensive escape relative to ancestral virus with the D614G substitution (B.1 lineage) when neutralized by sera from pre-Omicron vaccinated individuals and relative to Omicron BA.1 when neutralized by sera from Omicron BA.1 infected individuals. BA.2.86 and XBB.1.5 show similar viral infection dynamics in the VeroE6-TMPRSS2 and H1299-ACE2 cell lines. We also investigate the relationship of BA.2.86 to BA.2 sequences. The closest BA.2 sequences are BA.2 samples from Southern Africa circulating in early 2022. Similarly, many basal BA.2.86 sequences were sampled in Southern Africa. This suggests that BA.2.86 potentially evolved in this region, and that unobserved evolution led to escape from neutralizing antibodies similar in scale to recently circulating strains of SARS-CoV-2. © 2023, The Author(s).
Authors & Co-Authors
Khan, Khadija Akbar
South Africa, Durban
Africa Health Research Institute
South Africa, Durban
University of Kwazulu-natal
Lustig, Gila
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Reedoy, Kajal Soulakshana
South Africa, Durban
Africa Health Research Institute
Jule, Zesuliwe
South Africa, Durban
Africa Health Research Institute
Karim, Farina
South Africa, Durban
Africa Health Research Institute
South Africa, Durban
University of Kwazulu-natal
Ganga, Yashica
South Africa, Durban
Africa Health Research Institute
Bernstein, Mallory
South Africa, Durban
Africa Health Research Institute
Jackson, Laurelle
South Africa, Durban
Africa Health Research Institute
Mahlangu, Boitshoko
South Africa, Johannesburg
National Health Laboratory Service
Mnguni, Anele
South Africa, Johannesburg
National Health Laboratory Service
Nzimande, Ayanda
South Africa, Johannesburg
National Health Laboratory Service
Kekana, Dikeledi
South Africa, Johannesburg
National Health Laboratory Service
Ntozini, Buhle
South Africa, Johannesburg
National Health Laboratory Service
Manickchund, Nithendra
South Africa, Durban
University of Kwazulu-natal
Gosnell, Bernadett Isabel
South Africa, Durban
University of Kwazulu-natal
Lessells, Richard John
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
South Africa, Durban
Kwazulu-natal Research Innovation and Sequencing Platform
Karim, Quarraisha Abdool
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
United States, New York
Columbia University
Abdool Karim, Salim S.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
United States, New York
Columbia University
Moosa, Mohamed Yunus Suleman
South Africa, Durban
University of Kwazulu-natal
De Oliveira, Tulio
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
South Africa, Durban
Kwazulu-natal Research Innovation and Sequencing Platform
South Africa, Stellenbosch
Stellenbosch University
United States, Seattle
University of Washington
von Gottberg, Anne M.
South Africa, Johannesburg
National Health Laboratory Service
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
Wolter, Nicole
South Africa, Johannesburg
National Health Laboratory Service
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
Neher, Richard A.
Switzerland, Basel
Universitat Basel
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Sigal, Alex
South Africa, Durban
Africa Health Research Institute
South Africa, Durban
University of Kwazulu-natal
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Statistics
Authors: 24
Affiliations: 11
Identifiers
Doi:
10.1038/s41467-023-43703-3
ISSN:
20411723
Study Design
Cross Sectional Study
Study Locations
South Africa