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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Enhanced oxidative stress in coronary heart disease and chronic heart failure as indicated by an increased 8-epi-PGF
2α
European Journal of Heart Failure, Volume 7, No. 2, Year 2005
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Description
The role of oxidation injury as an important factor in the pathophysiology of cardiomyopathy (CMP) has recently gained increasing interest. Semiquantitative analysis for isoprostane, 8-epi-prostaglandin F 2α (8-epi-PGF2α), and oxidised low-density lipoprotein (ox-LDL) of coronary vascular tissue samples derived from CMP patients revealed an increased extent and intensity of uptake as compared to the respective controls. To evaluate oxidative stress in vivo, we examined plasma, serum, salivary, and urinary 8-epi-PGF2α in patients with dilated CMP (n=20) and ischemic CMP (n=20) with decreased left ventricular ejection fraction (LVEF). Patients with coronary heart disease (CHD) (n=20) and 20 healthy, age-matched, and sex-matched controls were investigated in parallel. 8-Epi-PGF2α levels were correlated with the functional severity of heart failure [New York Heart Association (NYHA) classification] and LVEF. 8-Epi-PGF2α levels were matched according to risk factors (smoking and hypercholesterolemia) and were significantly higher in patients with CMP as compared to healthy controls and patients with CHD in all investigated compartments. A positive correlation between NYHA stages and 8-epi-PGF2α, as well as a negative correlation to LVEF, could be demonstrated in a subgroup analysis. These findings reflect the enhanced oxidation injury in patients with CMP and, to a lesser extent, in CHD as compared to healthy controls, thus highly indicating the relevance of oxidative stress for the pathogenesis and progression of cardiovascular disease. © 2004 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
Authors & Co-Authors
Wolfram, Roswitha
Austria, Vienna
Medizinische Universität Wien
Oguogho, Anthony
Austria, Vienna
Medizinische Universität Wien
Nigeria, Ekpoma
Ambrose Alli University
Palumbo, B.
Italy, Perugia
Università Degli Studi Di Perugia
Sinzinger, Helmut F.
Austria, Vienna
Medizinische Universität Wien
Austria, Vienna
Wilhelm Auerswald Atherosclerosis Research Group
Statistics
Citations: 4
Authors: 4
Affiliations: 4
Identifiers
Doi:
10.1016/j.ejheart.2004.05.007
ISSN:
13889842
Research Areas
Noncommunicable Diseases
Violence And Injury