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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Reduced coenzyme Q
10
in female smokers and its association with lipid profile in a young healthy adult population
Archives of Medical Science, Volume 7, No. 6, Year 2011
Notification
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Description
Introduction: Cigarette smoking has a negative effect on body reserve of antioxidants and cholesterol metabolism. Coenzyme Q 10 (CoQ 10), a potent antioxidant synthesized as part of the cholesterol pathway, is a potential biomarker for systemic oxidative stress. We aimed to investigate gender variation in plasma lipid profile and CoQ 10 concentrations in healthy non-smokers and in smokers. Material and methods: The study included 55 cigarette smokers (25 females and 30 males) and 51 non-smokers (25 females and 26 males) with the age range from 21 to 45 years, and who had no history of alcohol abuse or chronic diseases such as diabetes mellitus or obesity. Coenzyme Q 10 plasma concentrations were measured by reverse-phase high performance liquid chromatography (HPLC) with ultraviolet detection. Fasting plasma glucose and lipid levels were determined by standard colorimetric methods. Results: Our results showed that CoQ 10 concentrations were significantly decreased in smokers, especially in females, than their non-smoker counterparts. Female smokers also exhibited a significant decrease in plasma concentrations of total cholesterol (TC), HDL-C, LDL-C, and atherogenic ratios HDL-C/TC and CoQ 10/LDL-C than male counterparts. Plasma triglyceride concentrations were increased in smokers irrespective of gender. Plasma CoQ 10 was relatively more associated with TC and LDL-C in female smokers than male smokers. Conclusions: The adverse effects of smoking on body reserve of antioxidants and cholesterol metabolism are greater in females than in males, partially as a result of decreased CoQ 10 plasma concentrations, HDL-C and total-cholesterol and abnormal atherogenicity indices. Copyright © 2011 Termedia & Banach.
Authors & Co-Authors
Al-Bazi, Maha Mohammed
Saudi Arabia, Jeddah
King Abdulaziz University
Elshal, Mohamed Farouk
Saudi Arabia, Jeddah
King Abdulaziz University
Khoja, Samir M.
Saudi Arabia, Jeddah
King Abdulaziz University
Statistics
Citations: 14
Authors: 3
Affiliations: 1
Identifiers
Doi:
10.5114/AOMS.2011.26605
ISSN:
17341922
Research Areas
Noncommunicable Diseases
Substance Abuse
Study Design
Cross Sectional Study
Participants Gender
Male
Female