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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Common Coinfections of Giardia intestinalis and Helicobacter pylori in Non-Symptomatic Ugandan Children
PLoS Neglected Tropical Diseases, Volume 6, No. 8, Article e1780, Year 2012
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Description
Background: The protozoan parasite Giardia intestinalis and the pathogenic bacterium Helicobacter pylori are well known for their high prevalences in human hosts worldwide. The prevalence of both organisms is known to peak in densely populated, low resource settings and children are infected early in life. Different Giardia genotypes/assemblages have been associated with different symptoms and H. pylori with induction of cancer. Despite this, not much data are available from sub-Saharan Africa with regards to the prevalence of different G. intestinalis assemblages and their potential association with H. pylori infections. Methodology/Principal Findings: Fecal samples from 427 apparently healthy children, 0-12 years of age, living in urban Kampala, Uganda were analyzed for the presence of H. pylori and G. intestinalis. G. intestinalis was found in 86 (20.1%) out of the children and children age 1<5 years had the highest rates of colonization. H. pylori was found in 189 (44.3%) out of the 427 children and there was a 3-fold higher risk of concomitant G. intestinalis and H. pylori infections compared to non-concomitant G. intestinalis infection, OR = 2.9 (1.7-4.8). No significant association was found in the studied population with regard to the presence of Giardia and gender, type of toilet, source of drinking water or type of housing. A panel of 45 G. intestinalis positive samples was further analyzed using multi-locus genotyping (MLG) on three loci, combined with assemblage-specific analyses. Giardia MLG analysis yielded a total of five assemblage AII, 25 assemblage B, and four mixed assemblage infections. The assemblage B isolates were highly genetically variable but no significant association was found between Giardia assemblage type and H. pylori infection. Conclusions/Significance: This study shows that Giardia assemblage B dominates in children in Kampala, Uganda and that the presence of H. pylori is an associated risk factor for G. intestinalis infection. © 2012 Ankarklev et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3429385/bin/pntd.0001780.s001.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3429385/bin/pntd.0001780.s002.txt
https://efashare.b-cdn.net/share/pmc/articles/PMC3429385/bin/pntd.0001780.s003.txt
https://efashare.b-cdn.net/share/pmc/articles/PMC3429385/bin/pntd.0001780.s004.txt
https://efashare.b-cdn.net/share/pmc/articles/PMC3429385/bin/pntd.0001780.s005.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3429385/bin/pntd.0001780.s006.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3429385/bin/pntd.0001780.s007.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3429385/bin/pntd.0001780.s008.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3429385/bin/pntd.0001780.s009.docx
Authors & Co-Authors
Ankarklev, Johan
Sweden, Uppsala
Biomedicinskt Centrum
Hestvik, Elin
Norway, Bergen
Universitetet I Bergen
Lebbad, Marianne
Sweden, Solna
Public Health Agency of Sweden
Lindh, Johan G.
Sweden, Solna
Public Health Agency of Sweden
Kaddu-Mulindwa, Deogratias H.
Uganda, Kampala
Makerere University
Andersson, Jan O.
Sweden, Uppsala
Biomedicinskt Centrum
Tylleskär, Thorkild
Norway, Bergen
Universitetet I Bergen
Tumwine, James Kashugyera
Uganda, Kampala
Makerere University
Svärd, Stäffan Gunnar
Sweden, Uppsala
Biomedicinskt Centrum
Statistics
Citations: 92
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pntd.0001780
ISSN:
19352727
e-ISSN:
19352735
Research Areas
Cancer
Environmental
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Uganda