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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Effect of olmesartan and pravastatin on experimental cerebral aneurysms in rats
Brain Research, Volume 1322, Year 2010
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Description
The major initiation process of intracranial aneurysms is thought to involve endothelial dysfunction due to hemodynamic stress. Angiotensin II type 1 receptor blockers and statins improve vascular endothelium function. The effects of olmesartan and pravastatin were investigated on the development of experimental aneurysms in rats. Eighty-three rats underwent aneurysm induction. Seven groups of 10-14 rats were treated with low or high dose olmesartan, low or high dose pravastatin, low doses of olmesartan and pravastatin, hydralazine, or no drug (control) for 12 weeks, when rats were sacrificed for vascular corrosion casting and scanning electron microscopy. Aneurysmal changes at the anterior cerebral-olfactory artery bifurcation were divided into stages 0 (no abnormality) to III (saccular aneurysm). Systolic arterial blood pressure was elevated over 170 mm Hg in the control, low dose pravastatin, and high dose pravastatin groups, but not in the other groups. The control group demonstrated aneurysmal changes in 100% and stage III in 50% of rats. Aneurysmal changes were observed in most rats in the other groups, but the incidence of stage III was 10% or less. The staging pattern showed significant differences between the groups (P = 0.028). Pravastatin reduced both stages III and II + III and olmesartan ameliorated stage III, implying that these may prevent aneurysmal formation through acting on different steps. (209 words). © 2010 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Kimura, Naoto
Japan, Sendai
Graduate School of Medicine
Shimizu, Hiroaki
Japan, Sendai
Graduate School of Medicine
Eldawoody, Hany A.Fikry
Japan, Sendai
Graduate School of Medicine
Egypt, Mansoura
Faculty of Medicine
Nakayama, Toshio
Japan, Sendai
Tohoku University
Saito, Atsushi
Japan, Sendai
Graduate School of Medicine
Tominaga, Teiji
Japan, Sendai
Graduate School of Medicine
Takahashi, Akira
Japan, Sendai
Graduate School of Medicine
Japan, Sendai
Tohoku University
Statistics
Citations: 40
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/j.brainres.2010.01.044
ISSN:
00068993
Research Areas
Noncommunicable Diseases
Study Design
Randomised Control Trial
Cohort Study