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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Transmission of Streptococcus pneumoniae in rural gambian villages: A longitudinal study
Clinical Infectious Diseases, Volume 50, No. 11, Year 2010
Notification
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Description
Background. To prepare for national introduction of a pneumococcal vaccine of restricted valency, we studied the pattern of nasopharyngeal carriage of Streptococcus pneumoniae and its transmission in Gambian villages over time. Methods. We collected nasopharyngeal swab specimens every 2 weeks from 158 villagers in 19 households in 2 villages over 1 year. We studied the prevalence and duration of S. pneumoniae carriage, the effect of household size and composition on carriage, and sequence type-specific carriage within and between households. Results. Ninety-seven percent of children and 85% of adults carried S. pneumoniae at some time. Fifty-three serotypes were represented among 1522 isolates. Carriage was more common among children than adults for all serotypes studied except 9V. There was an overall trend toward shorter carriage with increasing age (P = .043) and significant differences in carriage duration between serotypes. For most serotypes, the odds of being a carrier were greater if there were other carriers in the household. The prevalence of carriage varied by serotype. Most notably, serotype 5 carriage occurred in only 1 village and was transient. Multilocus sequence typing of serotype 6B isolates from 1 village revealed 8 different sequence types and strong evidence of nonrandom distribution among households (P <.001). Study by sequence type suggested household spread starting most commonly in children, followed by spread to adults. Conclusions. This longitudinal carriage study in Gambian villages provides unique information on the pattern of spread of S. pneumoniae in rural Africa and a baseline for evaluating the impact of the introduction of pneumococcal conjugate vaccine into the region. © 2010 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Hill, Philip C.
Unknown Affiliation
Townend, John A.
Unknown Affiliation
Antonio, Martin
Unknown Affiliation
Akisanya, Biodun
Unknown Affiliation
Ebruke, Chinelo
Unknown Affiliation
Lahai, George P.
Unknown Affiliation
Greenwood, Brian M.
Unknown Affiliation
Adegbola, Richard A.
Unknown Affiliation
Statistics
Citations: 87
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1086/652443
ISSN:
10584838
Research Areas
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative