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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Quality of life and depression among HIV-infected patients receiving efavirenz- or protease inhibitor-based therapy in Senegal
HIV Medicine, Volume 8, No. 2, Year 2007
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Description
Background: Efavirenz has been associated with neuropsychiatric disorders, but little is known about depression and quality of life in sub-Saharan Africa, where nonnucleoside reverse transcriptase inhibitor (NNRTI)-based regimens are still the first-line treatment recommended by the World Heath Organization (WHO) and are widely prescribed. Methods: In a cross-sectional study, we evaluated quality of life and depression among Senegalese patients receiving efavirenz- or protease inhibitor (PI)-based regimens. Two hundred consecutive patients who had been taking highly active antiretroviral therapy (HAART) for more than 6 months were asked to complete a questionnaire. Results: According to the Center for Epidemiologic Studies Depression Scale (CES-D), 18% had depression (19% for patients on a PI-based regimen and 17% for patients on efavirenz-based treatment). Fifty-nine per cent of the patients reported no health problems in the past 4 weeks. A quarter of patients had sleep disorders. Moderate or slight adverse events were reported by 28.5% of patients. Conclusions: Quality of life and depression scores remained good in both study groups. However, quality of life and depression should be monitored in follow-up of HIV-infected patients in sub-Saharan Africa. © 2007 British HIV Association.
Authors & Co-Authors
Poupard, Marie P.
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
Guèye, Ndèye Fatou Ngom
Senegal, Dakar
Fann University Hospital
Thiam, D.
Senegal, Dakar
Fann University Hospital
Ndiaye, Barra K.
Senegal, Dakar
Fann University Hospital
Girard, Pierre Marie
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
Delaporte, Éric
France, Montpellier
Ird Centre de Montpellier
Sow, Papa Salif
Senegal, Dakar
Fann University Hospital
Landman, Roland
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
Statistics
Citations: 52
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1111/j.1468-1293.2007.00435.x
ISSN:
14642662
e-ISSN:
14681293
Research Areas
Disability
Infectious Diseases
Mental Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Senegal