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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Mannose-binding lectin alleles in sub-Saharan Africans and relation with susceptibility to infections
Genes and Immunity, Volume 4, No. 5, Year 2003
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Description
Mannose-binding lectin (MBL) plays an important role in the early stages of primary infections and during the decay of maternal antibodies in infants. Various studies have looked at the relation between serum MBL concentrations, MBL gene alterations and susceptibility to infections. We investigated the distribution of variant MBL alleles in 626 unrelated adults from sub-Saharan African countries and looked for a potential relation between these alleles and the incidence, prevalence and death rate of tuberculosis for sub-Saharan Africa. We also evaluated the relation between MBL genotypes and susceptibility to HIV-1 infection in 188 Gabonese adults. We found that (i) the prevalence of the common variant MBL alleles is correlated with the incidence of tuberculosis in sub-Saharan Africa (r = 0.565), (ii) the mutant MBL G57E allele, in either the homozygous or compound heterozygous state, is associated with susceptibility to HIV-1 infection in the Gabonese population (P = 0.019). Our data plus those in the literature suggest that individuals who are homozygous for the mutant MBL alleles display increased susceptibility to infections. Interestingly, we found that individuals who are heterozygous for MBL mutations are much less susceptible to infections than those who are homozygous for the wild-type MBL allele. © 2003 Nature Publishing Group All rights reserved.
Authors & Co-Authors
Mombo, Landry Erik
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
France, Paris
Hôpital Robert-debré Ap-hp
Lu, Changyong
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Ossari, Simon A.
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Bedjabaga, Issa Ben
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Sica, Lucas
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Krishnamoorthy, Rajagopal
France, Paris
Hôpital Robert-debré Ap-hp
Lapouméroulie, Claudine L.
France, Paris
Hôpital Robert-debré Ap-hp
Statistics
Citations: 56
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1038/sj.gene.6363979
ISSN:
14664879
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study