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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The "child Health Evidence Week" and GRADE grid may aid transparency in the deliberative process of guideline development
Journal of Clinical Epidemiology, Volume 65, No. 9, Year 2012
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Description
Objective: To explore the evidence translation process during a 1-week national guideline development workshop ("Child Health Evidence Week") in Kenya. Study Design and Setting: Nonparticipant observational study of the discussions of a multidisciplinary guideline development panel in Kenya. Discussions were aided by GRADE (Grading of Recommendations Assessment, Development, and Evaluation) grid. Results: Three key thematic categories emerged: 1) "referral to other evidence to support or refute the proposed recommendations;" 2) "assessment of the presented research evidence;" and 3) "assessment of the local applicability of evidence." The types of evidence cited included research evidence and anecdotal evidence based on clinician experiences. Assessment of the research evidence revealed important challenges in the translation of evidence into recommendations, including absence of evidence, low quality or inconclusive evidence, inadequate reporting of key features of the management under consideration, and differences in panelists' interpretation of the research literature. A broad range of factors with potential to affect local applicability of evidence were discussed. Conclusion: The process of the "Child Health Evidence Week" combined with the GRADE grid may aid transparency in the deliberative process of guideline development, and provide a mechanism for comprehensive assessment, documentation, and reporting of multiple factors that influence the quality and applicability of guideline recommendations. © 2012 Elsevier Inc. All rights reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3413881/bin/mmc1.pdf
Authors & Co-Authors
Opiyo, Newton
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Norway, Oslo
Universitetet I Oslo
Shepperd, S.
United Kingdom, Oxford
University of Oxford
Musila, Nyokabi
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
English, Michael C.
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
United Kingdom, Oxford
University of Oxford
Fretheim, Atle
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Norwegian Knowledge Centre for Health Services
Statistics
Citations: 16
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1016/j.jclinepi.2012.03.004
ISSN:
08954356
e-ISSN:
18785921
Research Areas
Maternal And Child Health
Study Locations
Kenya