Computer assisted spectrophotometric analysis of three component mixtures (caffeine mixtures and codeine mixtures)

Two mixtures (caffeine mixture (I) and codeine mixture (II)) of 3-components, containing acetaminophen and salicylamide as majors, have been assayed using different computer-assisted spectrophotometric methods. These methods are the Unique Absorbance Method (UAM), the Unique Orthogonal Function Method (UOFM), and Unique Fourier Function Method (UFFM), and also their correspondences under the least squares approach. The parameters have been optimized for the accurate determination of the minor component caffeine in mixture (I). In mixture (II). however, codeine has been extracted - in two steps-prior to the correction of interferences from the major components acetaminophen and salicylamide. © 1992, Taylor & Francis Group, LLC. All rights reserved.