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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Prognostic significance of TIE2-expressing monocytes in hilar cholangiocarcinoma
Journal of Surgical Oncology, Volume 114, No. 1, Year 2016
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Description
Background and Objectives: Angiopoietins (Angs) play a pivotal role in angiogenesis and inflammation, and are associated with prognosis in malignancies. Monocyte express Ang-receptor TIE2 and correlate with prognosis in cancer. We aimed to investigate the prognostic value of Angs and TIE2-expressing monocytes (TEMs) in cholangiocarcinoma. Methods: We analyzed surgically resected tumor specimens of hilar cholangiocarcinoma (n = 47) for distribution of Angs (Ang 1/Ang 2) and TEMs, as defined by co-expression of CD14 and Ang receptor TIE2. Ang expression and abundance of TEMs were correlated with clinicopathologic characteristics, tumor recurrence and patients' survival. Results: High Ang 1 expression correlated with reduced metastasis (P < 0.05). Patients characterized by invading Ang-receptor bearing TEMs in tumor showed lower tumor recurrence (P < 0.05). Furthermore, TEMs in tumor and tumor invasive front correlated with increased survival (P < 0.05). TEMs in tumor invasive front were confirmed as independent prognosticator in multivariate survival analysis (P < 0.05). Conclusions: High Ang 1 expression in hilar cholangiocarcinoma and infiltration of TEMs defines a subgroup of patients with beneficial tumor characteristics and prolonged survival. Besides suggested functional links between Ang expression and recruitment of TEMs, our data have possible clinical implications as novel diagnostic tools. J. Surg. Oncol. 2016;114:91–98. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.
Authors & Co-Authors
Brandl, Andreas
Germany, Berlin
Charité – Universitätsmedizin Berlin
Robson, Simon Christopher
United States, Boston
Beth Israel Deaconess Medical Center
Pratschke, Johann
Germany, Berlin
Charité – Universitätsmedizin Berlin
Statistics
Citations: 22
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1002/jso.24249
ISSN:
00224790
Research Areas
Cancer