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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
HLA-A, -B, -C, -DRB1, and -DQB1 allele lineages and haplotype frequencies among saudis
Immunology and Immunogenetics Insights, Volume 6, No. 1, Year 2014
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Description
There are few reported studies on Saudi population for human leukocyte antigens (HLA) genes. We investigated allele lineages (two-digit) and haplotype frequencies of HLA-A, -B, -C, -DRB1, and -DQB1 loci in 499 healthy unrelated individuals, selected from potential bone marrow transplant (BMT) families' donors at King Fahad Medical City (KFMC), Saudi Arabia (SA). Genotyping was performed by Sequence Specific Oligonucleotide Probe (SSOP) utilizing a Luminex-based method. Allele lineages and haplotype frequencies were evaluated along with principal component analysis (PCA) to compare findings with previously reported data on Arab related populations. A total of 18 allele lineages for HLA-A, 28 for -B, 14 for -C, 13 for -DRB1, and 5 for -DQB1 were detected. High values for linkage disequilibrium indicators were found for B:C (D′ = 0.86599) and DRB1:DQB1 (D′ = 0.89468) loci. Additionally, PCA results confirmed previous findings on this population, but also indicated some genetic distances from other Arab related populations. The present study helps in further investigations of this population in anthropological analysis and HLA-associated disease studies. © the authors, publisher and licensee Libertas Academica Limited.
Authors & Co-Authors
Osman, Awad Elsid
Saudi Arabia, Riyadh
King Fahad Medical City
Gonzalez-Galarza, Faviel F.
United Kingdom, Liverpool
University of Liverpool
Mubasher, Mohamed E.
Saudi Arabia, Riyadh
King Fahad Medical City
Al-Harthi, Hanan
Saudi Arabia, Riyadh
King Fahad Medical City
ElSheikh, Nezar Eltayeb
Saudi Arabia, Riyadh
King Fahad Medical City
Berka, Noureddine
Canada, Calgary
University of Calgary
Middleton, Derek T.
United Kingdom, Liverpool
Liverpool University Hospitals Nhs Foundation Trust
ElGhazali, Gehad Eltayeb B.
United Arab Emirates, Abu Dhabi
Sheikh Khalifa Medical City
Statistics
Citations: 8
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.4137/III.S16796
e-ISSN:
11786345
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study