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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Comparison of immune restoration in early versus late alpha interferon therapy against hepatitis C virus
Journal of Virology, Volume 84, No. 19, Year 2010
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Description
Early alpha interferon (IFN-α) therapy against hepatitis C virus (HCV) rescues polyfunctional, virus-specific memory CD8+ T cells, but whether immune restoration is possible during late therapy remains controversial. We compared immune restoration of HCV-specific memory T cells in patients who cleared HCV infection spontaneously and following early or late IFN therapy. Multifunctional CD4+ and CD8+ memory T cells were detected in spontaneous resolvers and in individuals treated early following an acute infection. In contrast, limited responses were detected in patients treated during chronic infection, and the phenotype of HCV-specific cells was influenced by autologous viral sequences. Our data suggest that irreversible damage to the HCV-specific memory T-cell response is associated with chronic HCV infection. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Abdel-Hakeem, Mohamed S.
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Canada, Montreal
University of Montreal
Bédard, Nathalie
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Badr, Gamal
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Ostrowski, Mario A.
Canada, Toronto
University of Toronto
Seḱaly, Rafick Pierre
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Canada, Montreal
University of Montreal
Bruneau, Julie
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Canada, Montreal
University of Montreal
Willems, Bernard E.
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Canada, Montreal
University of Montreal
Heathcote, Elizabeth Jenny L.
Canada, Toronto
Toronto Western Hospital University of Toronto
Shoukry, Naglaa H.
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Canada, Montreal
University of Montreal
Statistics
Citations: 54
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1128/JVI.01094-10
ISSN:
0022538X
Research Areas
Infectious Diseases