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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Affinity Proteomics Reveals Elevated Muscle Proteins in Plasma of Children with Cerebral Malaria
PLoS Pathogens, Volume 10, No. 4, Article e1004038, Year 2014
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Description
Systemic inflammation and sequestration of parasitized erythrocytes are central processes in the pathophysiology of severe Plasmodium falciparum childhood malaria. However, it is still not understood why some children are more at risks to develop malaria complications than others. To identify human proteins in plasma related to childhood malaria syndromes, multiplex antibody suspension bead arrays were employed. Out of the 1,015 proteins analyzed in plasma from more than 700 children, 41 differed between malaria infected children and community controls, whereas 13 discriminated uncomplicated malaria from severe malaria syndromes. Markers of oxidative stress were found related to severe malaria anemia while markers of endothelial activation, platelet adhesion and muscular damage were identified in relation to children with cerebral malaria. These findings suggest the presence of generalized vascular inflammation, vascular wall modulations, activation of endothelium and unbalanced glucose metabolism in severe malaria. The increased levels of specific muscle proteins in plasma implicate potential muscle damage and microvasculature lesions during the course of cerebral malaria. © 2014 Bachmann et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3990714/bin/ppat.1004038.s001.pdf
Authors & Co-Authors
Bachmann, Julie
Sweden, Stockholm
The Royal Institute of Technology Kth
Burté, Florence
United Kingdom, London
Mrc National Institute for Medical Research
Pramana, Setia
Sweden, Stockholm
Karolinska Institutet
Conte, Ianina
United Kingdom, London
Mrc National Institute for Medical Research
Brown, Biobele Jotham
Nigeria, Ibadan
University College Hospital, Ibadan
Orimadegun, Adebola Emmanuel
Nigeria, Ibadan
University College Hospital, Ibadan
Ajetunmobi, Wasiu A.
Nigeria, Ibadan
University College Hospital, Ibadan
Afolabi, Nathaniel K.
Nigeria, Ibadan
University College Hospital, Ibadan
Akinkunmi, Francis Bola
Nigeria, Ibadan
University College Hospital, Ibadan
Omokhodion, Samuel Ilenre
Nigeria, Ibadan
University College Hospital, Ibadan
Akinbami, Felix Olukayode
Nigeria, Ibadan
University College Hospital, Ibadan
Shokunbi, Wuraola Adebola
Nigeria, Ibadan
University College Hospital, Ibadan
Kampf, Caroline
Sweden, Uppsala
Rudbecklaboratoriet
Pawitan, Yudi
Sweden, Stockholm
Karolinska Institutet
Uhleń, Mathias
Sweden, Stockholm
The Royal Institute of Technology Kth
Sodeinde, Olugbemiro O.
United Kingdom, London
Mrc National Institute for Medical Research
Nigeria, Ibadan
University College Hospital, Ibadan
Schwenk, Jochen M.
Sweden, Stockholm
The Royal Institute of Technology Kth
Wahlgren, Mats
Sweden, Stockholm
Karolinska Institutet
Fernandez-Reyes, Delmiro
United Kingdom, London
Mrc National Institute for Medical Research
Nigeria, Ibadan
University College Hospital, Ibadan
United Kingdom, Brighton
University of Sussex
Nilsson, Peter M.
Sweden, Stockholm
The Royal Institute of Technology Kth
Statistics
Citations: 47
Authors: 20
Affiliations: 6
Identifiers
Doi:
10.1371/journal.ppat.1004038
ISSN:
15537366
e-ISSN:
15537374
Research Areas
Infectious Diseases
Maternal And Child Health