Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Seroepidemiology of Toxoplasma gondii infection in women of child-bearing age in central Ethiopia
BMC Infectious Diseases, Volume 13, No. 1, Article 101, Year 2013
Notification
URL copied to clipboard!
Description
Background: Toxoplasma gondii infections during pregnancy can result in abortion or congenital defects. Prevalence and risk factors of toxoplasmosis in women of child-bearing age in Ethiopia are unknown. The current study was conducted with the objectives of estimating the seroprevalence and potential risk factors in acquiring T. gondii infection by women of child-bearing age in Central Ethiopia.Methods: A cross-sectional study was conducted from March 2011 to September 2011. Sera of 425 women were analyzed by indirect enzyme linked immunosorbent assay (ELISA). A questionnaire survey was administered for all study participants to gather information on risk factors.Results: The study revealed that anti- T. gondii IgG antibodies were detected in 81.4% of the samples of which 78.4% were positive for only IgG and 3.06% positive for both IgG and IgM antibodies. Seroprevalence of IgM antibodies to T. gondii (4.0%, 95% CI: 2.14, 5.86) was suggestive of recent infections. Of the 213 pregnant women 9 (4.2 %) were IgM reactive. Out of 17 potential risk factors investigated, univariate logistic regression showed significant association of T. gondii infection with study area, age, pregnancy status, raw vegetable consumption, source of water, presence of cats at home, contact with cats, HIV status and precaution during cats' feces cleaning (P ≤ 0.05). The final logistic regression model revealed that: the probability of acquiring T. gondii infection by women of Debre-Zeit was 4.46 times (95% CI of adjusted odds ratio [aOR]: 1.67, 11.89; P =0.003) higher compared to women of Ambo, pregnant women were twice (95% CI aOR: 1.13, 3.59; P = 0.018) more likely to be seropositive than non-pregnant women and women who consume raw vegetable were at increased risk of infection (aOR = 2.21, 95% CI: 1.03, 4.78; P = 0.043) than women who didn't consume.Conclusion: The seroprevalence of T. gondii infection in women of child-bearing age in Central Ethiopia is high. Study area, pregnancy and raw vegetable consumption are risk factors to acquire T. gondii infection. Educational program, antenatal screening of pregnant women and further epidemiological studies to uncover the economic and health impact of toxoplasmosis are suggested. © 2013 Gebremedhin et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Gebremedhin, Endrias Zewdu
Ethiopia, Ambo
Ambo University
Abebe, Anteneh Hailu
Ethiopia, Addis Ababa
Addis Ababa University
Tessema, Tesfaye Sisay
Ethiopia, Addis Ababa
Addis Ababa University
Desta, Kassu
Ethiopia, Addis Ababa
Addis Ababa University
Medhin, Girmay
Ethiopia, Addis Ababa
Addis Ababa University
Vitale, María
Italy, Palermo
Istituto Zooprofilattico Sperimentale Della Sicilia
Di Marco Lo Presti, Vincenzo
Italy, Palermo
Istituto Zooprofilattico Sperimentale Della Sicilia
Cox, Eric
Belgium, Ghent
Universiteit Gent
Dorny, Pierre
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Statistics
Citations: 107
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1186/1471-2334-13-101
e-ISSN:
14712334
Research Areas
Environmental
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Case-Control Study
Study Approach
Quantitative
Study Locations
Ethiopia
Participants Gender
Female