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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
NCF1 gene and pseudogene pattern: Association with parasitic infection and autoimmunity
Malaria Journal, Volume 7, Article 251, Year 2008
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Description
Background. Neutrophil cytosolic factor 1, p47phox (NCF1) is a component of the leukocyte NADPH oxidase complex mediating formation of reactive oxygen intermediates (ROI) which play an important role in host defense and autoimmunity. An individual genomic pattern of ncf1 and its two types of pseudogenes (reflected by the ΔGT/GTGT ratio) may influence the individual capacity to produce ROI. Methods. NCF1ΔGT/GTGT ratios were correlated with clinical parameters and ROI production during Plasmodium falciparum malaria and with susceptibility to the autoimmune disease multiple sclerosis (MS). Results. Among Gabonese children with severe malaria, ROI production from peripheral blood tended to be higher in individuals with a ΔGT/GTGT ratio ≤ 1:1. ΔGT/GTGT ratios were not associated with susceptibility to MS, but to age-of-onset among MS patients. Conclusion. The genomic pattern of NCF1 and its pseudogenes might influence ROI production but only marginally influence susceptibility to and outcome of malaria and MS. © 2008 Greve et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Greve, Bernhard
Germany, Tubingen
Hertie-institut Für Klinische Hirnforschung
Hoffmann, Peter
Germany, Tubingen
Hertie-institut Für Klinische Hirnforschung
Vonthein, Reinhard
Germany, Tubingen
Eberhard Karls Universität Tübingen
Kun, Juergen F.J.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Lell, Bertrand
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Mycko, Marcin P.
Poland, Lodz
Medical University of Lodz
Selmaj, Krzysztof W.
Poland, Lodz
Medical University of Lodz
Berger, Klaus Ulrich
Germany, Munster
University of Münster
Weissert, Robert
Germany, Tubingen
Hertie-institut Für Klinische Hirnforschung
Switzerland, Geneva
Serono International sa
Kremsner, Peter G.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Statistics
Citations: 18
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1186/1475-2875-7-251
e-ISSN:
14752875
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health