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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
In vitro cytotoxic and antiviral activities of Ficus carica latex extracts
Natural Product Research, Volume 25, No. 3, Year 2011
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Description
The latex of fig fruit (Ficus carica) is used in traditional medicine for the treatment of skin infections such as warts and also diseases of possible viral origin. Five extracts (methanolic, hexanic, ethyl acetate, hexane-ethyl acetate (v/v) and chloroformic) of this species were investigated invitro for their antiviral potential activity against herpes simplex type 1 (HSV-1), echovirus type 11 (ECV-11) and adenovirus (ADV). To evaluate the capacity of the extracts to inhibit the replication of viruses, the following assays were performed: adsorption and penetration, intracellular inhibition and virucidal activity. Observation of cytopathic effects was used to determine the antiviral action. The hexanic and hexane-ethyl acetate (v/v) extracts inhibited multiplication of viruses by tested techniques at concentrations of 78 μg mL-1. These two extracts were possible candidates as herbal medicines for herpes virus, echovirus and adenovirus infectious diseases. All extracts had no cytotoxic effect on Vero cells at all tested concentrations. © 2011 Taylor & Francis.
Authors & Co-Authors
Lazreg-Aref, Houda
Tunisia, Monastir
Institut Supérieur de Biotechnologie de Monastir
Gaaliche, Badii
Tunisia, Sousse
Institut Supérieur Agronomique de Chott Mériem
Fekih, Abdelwaheb
Tunisia, Monastir
Faculté de Médecine Dentaire de Monastir
Mars, Messaoud
Tunisia, Sousse
Institut Supérieur Agronomique de Chott Mériem
Aouni, Mahjoub
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Chaumon, Jean Pierre
France, Besancon
Faculté de Médecine
Saïd, Khaled H.
Tunisia, Monastir
Institut Supérieur de Biotechnologie de Monastir
Statistics
Citations: 95
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1080/14786419.2010.528758
ISSN:
14786419
e-ISSN:
14786427
Research Areas
Health System And Policy