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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
SCL/Tal-1 expression in T-acute lymphoblastic leukemia: An immunohistochemical and genotypic study
Human Pathology, Volume 26, No. 9, Year 1995
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Description
A comparative study of the immunohistochemical (Stem cell leukemia/T-cell acute leukemia [SCL/TAL-1] protein expression) and genotypic (deletions in the SCL/tal-1 gene) findings in T-acute lymphoblastic leukemia (T-ALL) is presented. Formalin-fixed tissue from 50 cases of T-ALL were stained with a novel monoclonal antibody, 2TL 242, which recognizes SCL/TAL-1 protein. Twenty-four cases showed nuclear immunolabeling of leukemic cells. Nuclear positivity was not evident in any other type of leukemia or lymphoma tested with the antibody. Genotypic analysis of 25 cases of T-ALL showed a deletion involving the SCL/tal-1 gene in nine cases. These results suggest that protein expression is not dependent on derangement of the SCL/tal-1 gene, because immnohistochemical detection of the protein was noted in the presence and absence of a tal-d1 deletion. © 1995.
Authors & Co-Authors
Chetty, Runjan M.
United Kingdom, Oxford
University of Oxford
France, Montpellier
Igmm Institut de Génétique Moléculaire de Montpellier
South Africa, Cape Town
Faculty of Health Sciences
Australia, Melbourne
Royal Melbourne Hospital
Denmark, Aarhus
University Institute of Pathology, Arhus
Denmark, Copenhagen
Københavns Universitet
Germany, Berlin
Freie Universität Berlin
Pulford, Karen
United Kingdom, Oxford
University of Oxford
France, Montpellier
Igmm Institut de Génétique Moléculaire de Montpellier
South Africa, Cape Town
Faculty of Health Sciences
Australia, Melbourne
Royal Melbourne Hospital
Denmark, Aarhus
University Institute of Pathology, Arhus
Denmark, Copenhagen
Københavns Universitet
Germany, Berlin
Freie Universität Berlin
Jones, Margaret
United Kingdom, Oxford
University of Oxford
France, Montpellier
Igmm Institut de Génétique Moléculaire de Montpellier
South Africa, Cape Town
Faculty of Health Sciences
Australia, Melbourne
Royal Melbourne Hospital
Denmark, Aarhus
University Institute of Pathology, Arhus
Denmark, Copenhagen
Københavns Universitet
Germany, Berlin
Freie Universität Berlin
Mathieu-Mahul, Daniele
United Kingdom, Oxford
University of Oxford
France, Montpellier
Igmm Institut de Génétique Moléculaire de Montpellier
South Africa, Cape Town
Faculty of Health Sciences
Australia, Melbourne
Royal Melbourne Hospital
Denmark, Aarhus
University Institute of Pathology, Arhus
Denmark, Copenhagen
Københavns Universitet
Germany, Berlin
Freie Universität Berlin
Close, Pauline M.
United Kingdom, Oxford
University of Oxford
France, Montpellier
Igmm Institut de Génétique Moléculaire de Montpellier
South Africa, Cape Town
Faculty of Health Sciences
Australia, Melbourne
Royal Melbourne Hospital
Denmark, Aarhus
University Institute of Pathology, Arhus
Denmark, Copenhagen
Københavns Universitet
Germany, Berlin
Freie Universität Berlin
Hussein, Sonay
United Kingdom, Oxford
University of Oxford
France, Montpellier
Igmm Institut de Génétique Moléculaire de Montpellier
South Africa, Cape Town
Faculty of Health Sciences
Australia, Melbourne
Royal Melbourne Hospital
Denmark, Aarhus
University Institute of Pathology, Arhus
Denmark, Copenhagen
Københavns Universitet
Germany, Berlin
Freie Universität Berlin
Pallesen, Gorm
United Kingdom, Oxford
University of Oxford
France, Montpellier
Igmm Institut de Génétique Moléculaire de Montpellier
South Africa, Cape Town
Faculty of Health Sciences
Australia, Melbourne
Royal Melbourne Hospital
Denmark, Aarhus
University Institute of Pathology, Arhus
Denmark, Copenhagen
Københavns Universitet
Germany, Berlin
Freie Universität Berlin
Ralfkiær, Elisabeth Methner
United Kingdom, Oxford
University of Oxford
France, Montpellier
Igmm Institut de Génétique Moléculaire de Montpellier
South Africa, Cape Town
Faculty of Health Sciences
Australia, Melbourne
Royal Melbourne Hospital
Denmark, Aarhus
University Institute of Pathology, Arhus
Denmark, Copenhagen
Københavns Universitet
Germany, Berlin
Freie Universität Berlin
Stein, Harald S.
United Kingdom, Oxford
University of Oxford
France, Montpellier
Igmm Institut de Génétique Moléculaire de Montpellier
South Africa, Cape Town
Faculty of Health Sciences
Australia, Melbourne
Royal Melbourne Hospital
Denmark, Aarhus
University Institute of Pathology, Arhus
Denmark, Copenhagen
Københavns Universitet
Germany, Berlin
Freie Universität Berlin
Gatter, Kevin C.
United Kingdom, Oxford
University of Oxford
France, Montpellier
Igmm Institut de Génétique Moléculaire de Montpellier
South Africa, Cape Town
Faculty of Health Sciences
Australia, Melbourne
Royal Melbourne Hospital
Denmark, Aarhus
University Institute of Pathology, Arhus
Denmark, Copenhagen
Københavns Universitet
Germany, Berlin
Freie Universität Berlin
Mason, David
United Kingdom, Oxford
University of Oxford
France, Montpellier
Igmm Institut de Génétique Moléculaire de Montpellier
South Africa, Cape Town
Faculty of Health Sciences
Australia, Melbourne
Royal Melbourne Hospital
Denmark, Aarhus
University Institute of Pathology, Arhus
Denmark, Copenhagen
Københavns Universitet
Germany, Berlin
Freie Universität Berlin
Statistics
Citations: 16
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1016/0046-8177(95)90089-6
ISSN:
00468177
Research Areas
Cancer
Genetics And Genomics