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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Dendritic cells are less susceptible to human immunodeficiency virus type 2 (HIV-2) infection than to HIV-1 infection
Journal of Virology, Volume 81, No. 24, Year 2007
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Description
Human immunodeficiency virus type 1 (HIV-1) infection of dendritic cells (DCs) has been documented in vivo and may be an important contributor to HIV-1 transmission and pathogenesis. HIV-1-specific CD4+ T cells respond to HIV antigens presented by HIV-1-infected DCs and in this process become infected, thereby providing a mechanism through which HIV-1-specific CD4 + T cells could become preferentially infected in vivo. HIV-2 disease is attenuated with respect to HIV-1 disease, and host immune responses are thought to be contributory. Here we investigated the susceptibility of primary myeloid DCs (mDCs) and plasmacytoid DCs (pDCs) to infection by HIV-2. We found that neither CCR5-tropic primary HIV-2 isolates nor a lab-adapted CXCR4-tropic HIV-2 strain could efficiently infect mDCs or pDCs, though these viruses could infect primary CD4+ T cells in vitro. HIV-2-exposed mDCs were also incapable of transferring virus to autologous CD4+ T cells. Despite this, we found that HIV-2-specific CD4+ T cells contained more viral DNA than memory CD4+ T cells of other specificities in vivo. These data suggest that either infection of DCs is not an important contributor to infection of HIV-2-specific CD4+ T cells in vivo or that infection of DCs by HIV-2 occurs at a level that is undetectable in vitro. The frequent carriage of HIV-2 DNA within HIV-2-specific CD4+ T cells, however, does not appear to be incompatible with preserved numbers and functionality of HIV-2-specific CD4+ T cells in vivo, suggesting that additional mechanisms contribute to maintenance of HIV-2-specific CD4+ T-cell help in vivo. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Duvall, Melody G.
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
United States, Bethesda
National Institutes of Health Nih
Loré, Karin
Sweden, Stockholm
Karolinska Institutet
United States, Bethesda
National Institutes of Health Nih
Blaak, Hetty
Netherlands, Rotterdam
Erasmus Mc
Ambrozak, David R.
United States, Bethesda
National Institutes of Health Nih
Adams, William C.
Sweden, Stockholm
Karolinska Institutet
United States, Bethesda
National Institutes of Health Nih
Santos, Kathlyn
United States, Bethesda
National Institutes of Health Nih
Geldmacher, Christof
United States, Bethesda
National Institutes of Health Nih
Mascola, John R.
United States, Bethesda
National Institutes of Health Nih
McMichael, Andrew James
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
Jaye, Assan
Gambia, Banjul
Medical Research Council Laboratories Gambia
Whittle, Hilton C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Rowland-Jones, Sarah Louise
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
Gambia, Banjul
Medical Research Council Laboratories Gambia
Koup, Richard A.
United States, Bethesda
National Institutes of Health Nih
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Statistics
Citations: 47
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1128/JVI.00976-07
ISSN:
0022538X
Research Areas
Genetics And Genomics
Infectious Diseases