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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Ethnic differences in proximal and distal tubular sodium reabsorption are heritable in black and white populations
Journal of Hypertension, Volume 27, No. 3, Year 2009
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Description
BACKGROUND: Segmental handling of sodium along the proximal and distal nephron might be heritable and different between black and white participants. METHODS: We randomly recruited 95 nuclear families of black South African ancestry and 103 nuclear families of white Belgian ancestry. We measured the (FENa) and estimated the fractional renal sodium reabsorption in the proximal (RNaprox) and distal (RNadist) tubules from the clearances of endogenous lithium and creatinine. In multivariable analyses, we studied the relation of RNaprox and RNadist with FENa and estimated the heritability (h) of RNaprox and RNadist. RESULTS: Independent of urinary sodium excretion, South Africans (n = 240) had higher RNaprox (unadjusted median, 93.9% vs. 81.0%; P < 0.001) than Belgians (n = 737), but lower RNadist (91.2% vs. 95.1%; P < 0.001). The slope of RNaprox on FENa was steeper in Belgians than in South Africans (-5.40 ± 0.58 vs. -0.78 ± 0.58 units; P < 0.001), whereas the opposite was true for the slope of RNadist on FENa (-3.84 ± 0.19 vs. -13.71 ± 1.30 units; P < 0.001). h of RNaprox and RNadist was high and significant (P < 0.001) in both countries. h was higher in South Africans than in Belgians for RNaprox (0.82 vs. 0.56; P < 0.001), but was similar for RNadist (0.68 vs. 0.50; P = 0.17). Of the filtered sodium load, black participants reabsorb more than white participants in the proximal nephron and less postproximally. CONCLUSION: Segmental sodium reabsorption along the nephron is highly heritable, but the capacity for regulation in the proximal and postproximal tubules differs between whites and blacks. © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Authors & Co-Authors
Bochud, Murielle
Switzerland, Lausanne
Institut Universitaire de Médecine Sociale et Préventive Lausanne
Staessen, Jan A.
Belgium, Leuven
Ku Leuven
Netherlands, Maastricht
Universiteit Maastricht
Maillard, Marc P.
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Mazeko, Muzi J.
South Africa, Johannesburg
University of the Witwatersrand
Kuznetsova, Tatiana N.
Belgium, Leuven
Ku Leuven
Woodiwiss, Angela Jill
South Africa, Johannesburg
University of the Witwatersrand
Richart, Tom
Belgium, Leuven
Ku Leuven
Netherlands, Maastricht
Universiteit Maastricht
Norton, Gavin R.
South Africa, Johannesburg
University of the Witwatersrand
Thijs, Lutgarde B.
Belgium, Leuven
Ku Leuven
Elston, Robert C.
United States, Cleveland
Case Western Reserve University
Burnier, Michel
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Statistics
Citations: 58
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1097/HJH.0b013e32832104b1
ISSN:
02636352
Research Areas
Cancer