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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Random Mating in a Natural Population of the Malaria Parasite Plasmodium Falciparum
Parasitology, Volume 109, No. 4, Year 1994
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Description
The genetic structure of a population of the malaria parasite Plasmodium falciparum has been examined in a village in Tanzania. Seventeen alleles of the merozoite surface protein MSP-1 and 23 of MSP-2 were detected by the polymerase chain reaction (PCR) among the blood parasites of the inhabitants. Most infections contained mixtures of genetically distinct parasite clones. PCR was then used to examine individual P. falciparum oocysts, the products of fertilization events, in wild-caught mosquitoes. Forty-five out of 71 oocysts were heterozygous for one or both genes, showing that crossing between clones was taking place frequently, following uptake of mixtures of gametocytes by the mosquitoes. The frequency of heterozygous forms showed that random mating events probably occurred within mosquito bloodmeals between gametes belonging to different parasite clones. © 1994, Cambridge University Press. All rights reserved.
Authors & Co-Authors
Babiker, Hamza Ali
United Kingdom, Edinburgh
The University of Edinburgh
Tanzania, Tanga
National Institute for Medical Research Tanga
United Kingdom, London
Imperial College London
Ranford-Cartwright, Lisa C.
United Kingdom, Edinburgh
The University of Edinburgh
Currie, D.
United Kingdom, Edinburgh
The University of Edinburgh
Statistics
Citations: 224
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1017/S0031182000080665
e-ISSN:
14698161
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Tanzania