The relationship between Bcl-2 oncogene expression and clinicopathological criteria in various stages of cervical neoplasia in Egyptian women

Purpose: To assess the degree of bcl-2 expression in the various stages of cervical neoplasia in a sample population of Egyptian women and relate the findings to clinicopathological criteria of invasive cervical cancer. Methods: Bcl-2 protein expression was assessed by immuno-histochemistry in 40 patients with cervical neoplasia (intraepithelial and invasive) in comparison to 20 patients with benign changes. Patients with invasive disease were followed up 2 years later and the outcome was correlated to the bcl-2 status at the time of diagnosis. Results: Bcl-2 expression increased from 20% in normal cervical tissue to 42.9% in cervical intraepithelial neoplasia grade II then dropped to 33% in invasive disease. Bcl-2 was not expressed (0%) in patients with advanced disease stage and grade nor in patients with lympho-vascular space invasion. Conclusion: Bcl-2 expression is reduced along the spectrum from benign towards invasive disease of the cervix. The maximum expression found in CIN II may suggest increased potential of progression to CIN III.