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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
A multicenter evaluation of diagnostic tools to define endpoints for programs to eliminate bancroftian filariasis
PLoS Neglected Tropical Diseases, Volume 6, No. 1, Article e1479, Year 2012
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Description
Successful mass drug administration (MDA) campaigns have brought several countries near the point of Lymphatic Filariasis (LF) elimination. A diagnostic tool is needed to determine when the prevalence levels have decreased to a point that MDA campaigns can be discontinued without the threat of recrudescence. A six-country study was conducted assessing the performance of seven diagnostic tests, including tests for microfilariae (blood smear, PCR), parasite antigen (ICT, Og4C3) and antifilarial antibody (Bm14, PanLF, Urine SXP). One community survey and one school survey were performed in each country. A total of 8,513 people from the six countries participated in the study, 6,443 through community surveys and 2,070 through school surveys. Specimens from these participants were used to conduct 49,585 diagnostic tests. Each test was seen to have both positive and negative attributes, but overall, the ICT test was found to be 76% sensitive at detecting microfilaremia and 93% specific at identifying individuals negative for both microfilariae and antifilarial antibody; the Og4C3 test was 87% sensitive and 95% specific. We conclude, however, that the ICT should be the primary tool recommended for decision-making about stopping MDAs. As a point-of-care diagnostic, the ICT is relatively inexpensive, requires no laboratory equipment, has satisfactory sensitivity and specificity and can be processed in 10 minutes-qualities consistent with programmatic use. Og4C3 provides a satisfactory laboratory-based diagnostic alternative. © 2012 Gass et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3260316/bin/pntd.0001479.s001.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3260316/bin/pntd.0001479.s002.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3260316/bin/pntd.0001479.s003.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3260316/bin/pntd.0001479.s004.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3260316/bin/pntd.0001479.s005.docx
Authors & Co-Authors
Gass, Katherine M.
United States, Decatur
Lymphatic Filariasis Support Center
de Rochars, Madsen V.E.B.
Unknown Affiliation
Boakye, Daniel Adjei
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Bradley, Mark H.
United Kingdom, Brentford
Glaxosmithkline Plc.
Fischer, Peter U.
United States, St. Louis
Washington University School of Medicine in St. Louis
Gyapong, John O.
Ghana, Accra
Ghana Health Service
Itoh, Makotoh
Japan, Nagakute
Aichi Medical University School of Medicine
Ituaso-Conway, Nese
Tuvalu
Ministry of Health
Joseph, Hayley
Australia, Townsville
James Cook University
Kyelem, Dominique
United States, Decatur
Lymphatic Filariasis Support Center
Laney, Sandra J.
United States, Northampton
Smith College
Legrand, Anne Marie
French Polynesia, Papeete
Institut Louis Malarde
Liyanage, Tilaka S.
Sri Lanka, Colombo
Anti Filariasis Campaign
Melrose, Wayne D.
Australia, Townsville
James Cook University
Mohammed, Khalfan Abdallah
Tanzania, Dar es Salaam
Ministry of Health and Social Welfare Dar es Salaam
Pilotte, Nils
United States, Northampton
Smith College
Ottesen, Eric A.
United States, Decatur
Lymphatic Filariasis Support Center
Plichart, Catherine
French Polynesia, Papeete
Institut Louis Malarde
Ramaiah, Kapa Dasaradha
India, Puducherry
Vector Control Research Centre India
Rao, Ramakrishna
United States, St. Louis
Washington University School of Medicine in St. Louis
Talbot, Jeffrey
United States, Decatur
Lymphatic Filariasis Support Center
Weil, Gary J.
United States, St. Louis
Washington University School of Medicine in St. Louis
Williams, Steven A.
United States, Northampton
Smith College
Won, Kimberly Y.
United States, Atlanta
Centers for Disease Control and Prevention
Lammie, Patrick J.
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 113
Authors: 25
Affiliations: 14
Identifiers
Doi:
10.1371/journal.pntd.0001479
ISSN:
19352727
e-ISSN:
19352735
Study Design
Cross Sectional Study
Study Approach
Quantitative