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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Parity and breastfeeding are protective against breast cancer in Nigerian women
British Journal of Cancer, Volume 98, No. 5, Year 2008
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Description
As the relation between reproductive factors and breast cancer risk has not been systematically studied in indigenous women of sub-Saharan Africa, we examined this in a case-control study in Nigeria. In-person interviews were conducted using structured questionnaires to collect detailed reproductive history in 819 breast cancer cases and 569 community controls between 1998 and 2006. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CI). Compared with women with menarcheal age <17 years, the adjusted OR for women with menarcheal age ≥17 years was 0.72 (95% CI: 0.54-0.95, P=0.02). Parity was negatively associated with risk (P-trend=0.02) but age at first live birth was not significant (P=0.16). Importantly, breast cancer risk decreased by 7% for every 12 months of breastfeeding (P-trend=0.005). It is worth noting that the distribution of reproductive risk factors changed significantly from early to late birth cohorts in the direction of increasing breast cancer incidence. Our findings also highlight the heterogeneity of breast cancer aetiology across populations, and indicate the need for further studies among indigenous sub-Saharan women. © 2008 Cancer Research UK.
Authors & Co-Authors
Huo, Dezheng
United States, Chicago
The University of Chicago
Adebamowo, Clement
Nigeria, Ibadan
University College Hospital, Ibadan
Ogundiran, Temidayo Olusade
Nigeria, Ibadan
University College Hospital, Ibadan
Akang, Effiong E.U.
Nigeria, Ibadan
University College Hospital, Ibadan
Campbell, Oladapo Babatunde
Nigeria, Ibadan
University College Hospital, Ibadan
Adenipekun, Adeniyi Abidemi
Nigeria, Ibadan
University College Hospital, Ibadan
Cummings, S.
United States, Chicago
The University of Chicago
Fackenthal, James D.
United States, Chicago
The University of Chicago
Ademuyiwa, Foluso O.
United States, Chicago
The University of Chicago
Ahsan, Habibul A.M.Nazmul
United States, Chicago
The University of Chicago
Olopade, Olufunmilayo Ibironke
United States, Chicago
The University of Chicago
Statistics
Citations: 136
Authors: 11
Affiliations: 2
Identifiers
Doi:
10.1038/sj.bjc.6604275
e-ISSN:
15321827
Research Areas
Cancer
Genetics And Genomics
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Case-Control Study
Study Locations
Nigeria
Participants Gender
Female