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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Short-Course Antibiotic Therapy for Urinary Tract Infections in Children: A Methodological Review of the Literature
American Journal of Diseases of Children, Volume 142, No. 1, Year 1988
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Description
We performed a methodological review of 14 published clinical trials of short-course (≤4 days) vs conventional (seven to ten days) antibiotic therapy for urinary tract infection in children. Four reviewers independently assessed each study, without knowledge of authorship, according to 35 criteria, 14 of which were considered critical for this type of study. Reviewer ratings were summed so that any study could receive a potential score of 140 for all criteria and 56 for the critical criteria. Only one study met more than 75% of all the criteria, whereas four studies met 75% of critical criteria. Two studies found short-course antibiotic therapy significantly less effective than conventional therapy. The remaining 12 had insufficient sample size to warrant the conclusion that the two therapies were equivalent. We conclude that there is insufficient evidence to warrant the use of short-course antibiotic therapy for urinary tract infection in children and that a much larger study, with attention to some of the details described, is warranted. © 1988, American Medical Association. All rights reserved.
Authors & Co-Authors
Moffatt, Michael E.K.
Canada, Winnipeg
University of Manitoba
Embreé, Joanne E.
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
Grimm, Paul
Canada, Winnipeg
University of Manitoba
Canada, Halifax
Izaak Walton Killam Hospital for Children
Law, Barbara J.
Canada, Winnipeg
University of Manitoba
Statistics
Citations: 36
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1001/archpedi.1988.02150010067024
ISSN:
0002922X
e-ISSN:
15383628
Research Areas
Maternal And Child Health