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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Hepatitis B Virus-Hepatitis D Virus mother-to-child co-transmission: A retrospective study in a developed country
Liver International, Volume 38, No. 4, Year 2018
Notification
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Description
Background & Aims: Hepatitis B Virus (HBV) DNA during chronic infection can reach levels at which mother-to-child (MTC) transmission frequently occurs despite passive-active immunization of newborns. Hepatitis D Virus (HDV) RNA can reach high levels, we assessed HBV/HDV MTC co-transmission. Methods: Monocentric retrospective study (registered in ClinicalTrials.gov (NCT02044055)), after informed consent in HBV/HDV co-infected women pregnant between 01/01/2004 and 01/01/2015 in Paris, France. The children were tested when 24 months of age or older. Results: Twenty-two (3%) of 742 HBV infected women, HDV co-infected, gave birth to 54 children during the study period. HBV DNA was above 5 Log10 I.U/mL in 10 pregnancies previous any treatment, with HDV RNA of less than 2.3 Log10 I.U/mL. HDV RNA was above 5 Log10 I.U/mL in eight pregnancies previous any treatment, with HBV DNA of less than 1.5 Log10 I.U/mL. Inverse patterns of HBV DNA and HDV RNA were observed in 17 of 35 (49%) pregnancies: 13 (76%) received no HBV treatment; four (24%) were treated. HBV DNA was under 5 Log10 I.U/mL in 46 of the 50 assessed women (92%) at birth. Of the 36 assessed children, given passive-active immunization, 24 (66%) were protected, 10 (28%) were neither infected nor protected, one was chronically HBV infected, and one had a past HBV infection. HDV Ab was negative in the 36 children. Conclusions: These results suggest that HBV/HDV MTC co-transmission is exceptional. Studies are needed, mainly in developing countries. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Authors & Co-Authors
Sellier, Pierre Olivier
France, Paris
Hôpital Fernand-widal
Maylin, Sarah
France, Paris
Hôpital Fernand-widal
Brichler, Ségolène
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Berçot, Béatrice
France, Paris
Hôpital Fernand-widal
Pogliaghi, Manuela
France, Paris
Hôpital Fernand-widal
Gordien, Emmanuel
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Simon, Franćois
France, Paris
Hôpital Fernand-widal
Statistics
Citations: 33
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1111/liv.13556
ISSN:
14783223
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Participants Gender
Female