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Sterile Lung Inflammation Induced by Silica Exacerbates Mycobacterium tuberculosis Infection via STING-Dependent Type 2 Immunity

Cell Reports, Volume 27, No. 9, Year 2019

Benmerzoug et al. mechanistically dissect how sterile lung inflammation induced by silica exacerbates M. tuberculosis infection (silicotuberculosis). Silica exposure induces self-dsDNA release and STING pathway activation, which potentiate the host response to M. tuberculosis DNA via initiation of type 2 immunity. Thus, STING and nucleic acids represent interesting therapeutic targets for silicotuberculosis.

Statistics
Citations: 33
Authors: 13
Affiliations: 8
Identifiers
Doi: 10.1016/j.celrep.2019.04.110
e-ISSN: 22111247
Research Areas
Genetics And Genomics

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