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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Risk of lung cancer in patients with preinvasive bronchial lesions followed by autofluorescence bronchoscopy and chest computed tomography
Lung Cancer, Volume 72, No. 3, Year 2011
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Description
To assess risk of lung cancer (LC) in patients with preinvasive bronchial lesions and to identify factors associated with higher risk. Methods: 124 patients with one or more preinvasive bronchial lesions and normal chest computed tomography (CT) (mean age 66.7 years, 121 males and 3 females), followed-up by white light and autofluorescence bronchoscopy (AFB) every 4-6. mo and chest CT every 6-12. mo, end points were development of carcinoma in situ (CIS) or LC. Results: Among 124 patients with 240 preinvasive bronchial lesions, 20 CIS or LC lesions were detected during follow-up in 20 (16%) patients, 7 were detected as new endobronchial lesions, 10 as new peripheral lesions and 3 as local progression from severe dysplasia to CIS. Median time to progression from the same site or development of CIS/LC elsewhere was 24 months (range: 6-54. mo). The Cumulative risk of development of CIS/LC was 7% at one year, 20% at three years and 44% at 5 years. Among detected lung cancers, 80% were stage 0 or stage I and underwent treatment with curative intent. Diagnosis of new SD during follow-up (p = 0.0001), chronic obstructive pulmonary disease (COPD) (p = 0.001) or smoking index >52 pack-year (p = 0.042) was associated with higher risk. Even after controlling for other risk factors, COPD was associated with risk for lung cancer. Baseline lesion grade was not predictive of patient outcome (p = 0.146). Conclusion: Patients with preinvasive bronchial lesions, especially those with new SD during follow-up, COPD or smoking >52 pack-year are at high risk of LC, AFB and CT follow-up facilitated early detection and treatment with curative intent. © 2010 Elsevier Ireland Ltd.
Authors & Co-Authors
Rashad, Alaa
Japan, Chiba
Chiba University
Egypt, Asyut
Faculty of Medicine
Shibuya, Kiyoshi
Japan, Chiba
Chiba University
Japan, Matsudo
Matsudo City Hospital
Fujiwara, Taiki
Japan, Chiba
Chiba University
Wada, Hironobu
Japan, Chiba
Chiba University
Hoshino, Hidehisa
Japan, Chiba
Chiba University
Yoshida, Shigetoshi
Japan, Chiba
Chiba University
Suzuki, Makoto
Japan, Chiba
Chiba University
Hiroshima, Kenzo
Japan, Chiba
Chiba University
Nakatani, Yukio
Japan, Chiba
Chiba University
Hussein, Aliae A.R.Mohamed
Egypt, Asyut
Faculty of Medicine
Elkholy, Maha Mohamed S.A.
Egypt, Asyut
Faculty of Medicine
Mahfouz, Tarek Abd El Hakeem
Egypt, Asyut
Faculty of Medicine
Yoshino, Ichiro
Japan, Chiba
Chiba University
Statistics
Citations: 18
Authors: 13
Affiliations: 3
Identifiers
Doi:
10.1016/j.lungcan.2010.09.014
ISSN:
01695002
Research Areas
Cancer
Health System And Policy
Noncommunicable Diseases
Study Design
Cohort Study
Participants Gender
Female